Award Data

HSV-l is the major infectious cause of corneal blindness in the United States. Redox has synthesized transition metal complexes (CTC compounds) exhibiting potent in vitro activity against herpes group viruses. Significantly, the mode of action of these novel compounds differs from currently available antiviral nucleoside analogs. One CTC compound exhibits pronounced efficacy in the topical therapy ...

No semi-structured clinical interview currently exists that (a) assesses the severity of DSM-IV andsubstance use disorders and (b) is designed to be sensitive to changes in clinical status. The Psychfor Substance and Mental Disorders (PRISM) is a clinician-administered, semi-structured interview thprovides reliable diagnoses of drug and alcohol disorders. Preliminary psychometric analyses of PRIt ...

We recently introduced a novel ultrasound indicator dilution method which has the potential to becoeconomical measurement tool of hemodialysis access flow and recirculation during patient dialysis. Wtechnologies in an animal model, in collaboration with researchers at the NYS College of VeterinaryUniversity; support clinical evaluations in key hemodialysis treatment centers in order to establishth ...

An individual who is exposed to HIV-1 contaminated blood or other bodily fluids runs a significantbecoming infected with the virus. The goal of post-exposure prophylaxis is to protect exposed indivianticipated infection. The major clinical settings for HIV-1 post- exposure prophylactic therapy inctransmission as a result of accidental needle-stick injuries sustained by health care workers and vein ...

Research is providing increasing evidence of the potential therapeutic effectsof the physical environment for people with dementia in long-term care settings. Despite this, facilitieshave limited options for learning how to create more supportive environments. Hence few facilities areincorporating those environmental features cited as important in the research literature. Existing optionsare eithe ...

We will support performance of a research study to address the feasibility for developing anexperimental metered delivery foam preparation for the rectal delivery of an antiepileptic drug for usein patients unable to receive medication via oral and/or intravenous routes. The end product of thiscontract is a final report, which shall summarize results of the research work conducted hereunder.Specif ...

E. coli Ol57:H7 is an emerging food-borne pathogen with substantial morbidity and mortality.There are an estimated 20,000 cases of E. coli 0157:H7 infection per year in the United States.However, only 11 states require reporting of the cases to the State Health Department; hence, the actualnumber of cases is likely to be much higher. Twenty-two percent of children acquiring E. coli Ol57:H7infectio ...

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Acquired Immunodeficiency Syndrome (AIDS), a disease affecting millions of individuals worldwide, has a high incidence of patient mortality. The etiological agent of this disease, the infectious retrovirus HIV-l, has proven refractory to therapeutic intervention. The drugs used in the clinic today only target the viral reverse transcriptase. At best, such drugs temporarily delay disease progressio ...

Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. The markers will alsob ...