Award Data

Research is providing increasing evidence of the potential therapeutic effectsof the physical environment for people with dementia in long-term care settings. Despite this, facilitieshave limited options for learning how to create more supportive environments. Hence few facilities areincorporating those environmental features cited as important in the research literature. Existing optionsare eithe ...

E. coli Ol57:H7 is an emerging food-borne pathogen with substantial morbidity and mortality.There are an estimated 20,000 cases of E. coli 0157:H7 infection per year in the United States.However, only 11 states require reporting of the cases to the State Health Department; hence, the actualnumber of cases is likely to be much higher. Twenty-two percent of children acquiring E. coli Ol57:H7infectio ...

Our research will identify and develop a new type of polymorphic DNA marker that will allowsimplification and acceleration of genetic analyses. These multiplex-compatible amplifiable markers willhave the advantage of simplified analysis versus current PCR-based marker systems, allowing detectionin a new agarose gel format rather than requiring denaturing polyacrylamide gels. The markers will alsob ...

THE DEVELOPMENT OF RAPID SIMPLE METHODS FOR SEQUENCING DNA HAS LED TO A REQUIREMENT FOR THE DAY TO DAY USE OF COMPUTERSIN THE MOLECULAR BIOLOGY LABORATORY. THE LOW COST OF MICROCOMPUTERS HAS GENERATED CONSIDERABLE INTEREST IN THESE SMALL MACHINES AS THE MOST COST-EFFECTIVE WAY TO MEET THIS REQUIREMENT. THE PURPOSE OF THE FEASIBILITY STUDY PROPOSED HERE IS TO DEFINE THE HARDWARE AND SOFTWARE REQUIR ...

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THE OVERALL OBJECTIVE OF THIS RESEARCH IS TO DEVELOP A HIGHLY AUTOMATED DNA SEQUENCING SYSTEM THAT CAN BE SOLD TO MOLECULAR BIOLOGY RESEARCHERS INTERESTED IN CARRYING OUT LARGE SCALE SEQUENCING PROJECTS. THE COMPLETE SYSTEM WILL INCLUDE ROBOTIC REACTION PREPARATION, HIGH CAPACITY GEL ELECTROPHORESIS SYSTEM, ROBOTIC GEL LOADING AUTOMATIC GEL FILM READER AND SOFTWARE FOR MANAGING THE DATA. THE SPECI ...

ALCOHOL USAGE OVER TIME RESULTS IN A NUMBER OF METABOLIC ALTERATIONS TO SEVERAL ORGAN SYSTEMS, INCLUDING CHANGES IN LIVER FUNCTION. ONE OF THE LATTER CHANGES IS THE PRODUCTION AND SECRETION INTO THE BLOOD OF AN ISOFORM OF THETRANSFERRIN MOLECULE. THE PI 5.7-TRANSFERRIN ISOFORM CAN BEDETECTED BY ISOELECTRIC FOCUSING, AND ITS QUANTITIES HAVE BEEN SHOWN TO DIRECTLY CORRELATE WITH THE AMOUNT OF ALCOHO ...