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ABSTRACT Colorectal cancerCRCrepresents the fourth most commonly diagnosed cancer withnew cases each yearUnfortunatelyCRC results in a disproportionate number of deathsprojected indue to advanced stage at diagnosisthe aggressive phenotype of the disease and lack of effective therapeuticsGreater thanof CRC patients possess activating mutations in the WNT signaling pathwayWNT pathway activation is a ...

Project SummaryBladder cancer is the fifth most common cancer in the U SUp toof patients initially present with non muscle invasive bladder cancerNMIBCconfined to the mucosa of the bladderThese patients are treated by tumor resection followed by intravesical chemotherapy or Bacillus Calmette Gu rinBCGtherapyDespite treatmentup toof patients will experience tumor recurrence andof theseaboutwill und ...

Project Summary Antibiotic resistance has recently emerged as a global threat for healthcare systemsAn increasing number of pathogenic bacteria are acquiring antibiotic resistanceand new forms of resistance are continuously emerging with alarming speed across international boundariesIn the USalonethe Center for Disease Control and PreventionCDChas estimatedmillion patients per year are directly af ...

Project Summary Abstract TuberculosisTBis one of the leading causes of morbidity and mortality from infectious disease worldwide with an estimatedmillion cases of active TB andmillion deaths from the disease annuallyDespite emerging new technologiesculture remains the gold standard in TB diagnosis and therapeutic monitoringInthe World Health OrganizationWHOrecommended the use of a liquid culturing ...

ABSTRACT The principal business interestiFIT Prosthetics LLCwith STTR fundingcreated a new transtibial prosthetic device and demonstrated its safetycomfortand functionIn contrast to conventionally made prosthetic limbsthe iFIT prosthesis is easily fit and aligned on the residual limb in a single sessionDue to its substantial adjustability and customized inner linerthe iFIT device is a comfortable ...

DESCRIPTIONprovided by applicantWe have engineered a synthetic antibody that neutralizesof HIV strainsThis antibody is built from the parts of CDand CCRthat are recognized by HIVand is named "eCDIg " The goal of our research program is now to maximize its efficacyA fundamental question for our effort and for the field as a whole isWhich isotype of IgG has the properties that are most important for ...

Respiratory infections with influenza viruses cause severe morbidity and mortality in humans and animals worldwideImportantlyin humansthe majority of morbidity and mortality following flu infection is seen in older individualsrtyears oldYetclear understanding of how aging impacts on innate immune responsesand how to improve vaccine design in this age group is lackingRestimulating preexisting memor ...

Scarab Genomicsgoal is to commercialize carrier proteins for conjugate vaccine manufactureThis proposal focuses on two bacterial carrier proteins that have been approved by the FDA and that are in use in pre clinical and clinical studiesExoprotein AEPAfrom Pseudomonas aeruginosa and Protein DPDfrom non typeable Haemophilus influenzaeThese proteins are difficult to make by the conventional Ecoli fe ...

Despite the tremendous success of short read next generation sequencingNGStechnologiestheir inherent inability to establish long range connectivity makes fundamental tasks such as genome closurehaplotype phasing and alternatively spliced transcript characterization all but impossibleNowtwo long read sequencing providersPacific BiosciencesPacBioand Oxford Nanopore TechnologiesONTare producing data ...

This project describes a novel approach to automate and individualize the signal processing strategy for hearing aidsHAthat can result in improved speech intelligibility in background noisegreater user satisfaction and acceptance for HAsand reduce barriers to affordable hearing health careThe proposed Individualized Signal Processing StrategyISPSis based on individual performance on categorical pe ...