Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Low-cost Low-power Wireless Sensor Network Based Highway Incident Detection & Warning System

    SBC: Central Signal LLC            Topic: 07FH4

    More that 52% of the U.S. highway congestion in urban areas is a direct result of highway incidents. Federal and State transportation authorities are searching for quick, low-cost and efficient highway incident detection and warning systems. Several solutions have been proposed but none could meet the requirements of transportation authorities. Central Signal, funded by federal agencies, has done ...

    SBIR Phase I 2008 Department of Transportation
  2. Novel Approach for Fast and Economic Manufacturing of Human Antibodies

    SBC: ALPHA UNIVERSE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): A growing number of potential native and engineered biothreat agents effectively limit the proactive protection of public health through vaccination. An alternative approach relies on the use of corresponding protective antibodies that are pre-made and are used as injectable drugs in reactive rather than proactive mode. The implementation of this approach, how ...

    SBIR Phase I 2008 Department of Health and Human Services
  3. Miniature Ambulatory Hot Flash Monitor

    SBC: BAHR MANAGEMENT, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): We were originally awarded SBIR grant R43AT003183-01 in September 2005 to develop a miniature, wireless skin conductance monitor to measure hot flash frequency and severity. A prototype monitor was developed that measur es changes in sternal skin conductance and uses pattern recognition software to recognize the frequency, and timing of hot flashes. The electro ...

    SBIR Phase II 2008 Department of Health and Human Services
  4. Fluorescent HTS Assays for Methyltransferases in Neurodegenerative Diseases

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Methylation is a ubiquitous and reversible covalent modification used to control the function of diverse biomolecules including their activity, stability and localization. Like phosphorylation, methylation is used to mo dulate protein function, but in addition many small molecules are regulated by methylation including hormones, neurotransmitters, xenobiotics, ...

    SBIR Phase II 2008 Department of Health and Human Services
  5. Generic Fluorescent HTS Assay for Oxidoreductases

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There is a high level of pharmaceutical interest in targeting enzymes that catalyze oxidation and reduction reactions for therapeutic intervention. Validated redox enzyme targets include HMG-CoA reductase, the target of statin drugs like Lipitor that are used to treat hypercholesterolemia, and 51-reductase, the target of drugs used to treat benign prostatic hy ...

    SBIR Phase I 2008 Department of Health and Human Services
  6. Microfluidic Viral Infection Assay

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): In less than one year the 1918 Spanish flu pandemic claimed over 20 million lives worldwide, killing 675,000 Americans, more than 10 times the number of deaths to US servicemen in World War I. A similar strain of the vi rus that caused the 1918 pandemic could today kill 2 million Americans and force 10 million to be hospitalized. Although anti-viral drugs are k ...

    STTR Phase I 2008 Department of Health and Human Services
  7. SBIR TOPIC 245 "PREDICTIVE EFFICACY SCREENING IN CANCER STEM CELLS USING METABOLO

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: N/A

    Cancer stem cells (CSCs) are a critical tumor subpopulation that may cause local recurrences that plague patients with advanced solid malignancies, even after maximal therapeutic efforts. CSCs can self-renew, differentiate into multiple lineages, resist radiation and chemotherapy, and efficiently initiate and propagate tumor formation. These characteristics make the quest for assays to measure dru ...

    SBIR Phase I 2008 Department of Health and Human Services
  8. Synthetic Viscosupplement for Treating Osteoarthritis

    SBC: FLEX BIOMEDICAL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Osteoarthritis is an incurable and chronic form of arthritis that is characterized by a breakdown of cartilage and synovial fluid in the joints. This debilitating disease currently affects 21 million people in the US co sting billions of dollars. The goal of this project is to develop a novel, synthetic polymer to be used to supplement synovial fluid in the joi ...

    SBIR Phase I 2008 Department of Health and Human Services
  9. Development of a Convenient, Automated, Objective Measure of Depression

    SBC: HEALTHCARE TECHNOLOGY SYSTEMS, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Depression is a serious, debilitating disorder that affects millions of people, but treatment research is hampered by the limited reliability of current outcome measures that are often biased by a number of methodologic al and clinical factors. Such considerations resulted in the issuance of Program Announcement 06-016, Development of Biomarkers for Mental Hea ...

    SBIR Phase II 2008 Department of Health and Human Services
  10. Development of the Standard for Clinical Breast Perfusion Imaging

    SBC: Imaging Biometrics, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Currently detection of breast tumors is most often accomplished with x-ray mammography. This is true despite the fact that mammography misses 5-15% of palpable breast cancers and has a positive predictive value of only 15-30%. Consequently, mammography requires a much higher rate of biopsy than occurrences of malignancy. Alternatively, contrast-enhanced magnet ...

    SBIR Phase I 2008 Department of Health and Human Services
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