Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Screening of FoxA1-ER-DNA disruptors for development of breast cancer therapeutic

    SBC: Proteovista LLC            Topic: NCI

    DESCRIPTION (provided by applicant): Estrogen receptor a (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer cells is guided by DNA binding pioneer factor proteins such as FoxA1. Although tamoxifen is asuccessful therapeutic for suppressing ER-mediated gene regulation, resistance to tamoxifen occurs in most breast cancer patients within five ye ...

    SBIR Phase I 2011 Department of Health and Human Services
  2. High Throughput Method to Assess SNP Functionality in Prostate Cancer

    SBC: Proteovista LLC            Topic: NCI

    DESCRIPTION (provided by applicant): A critical unmet need in implementing personalized medicine is the ability to sort through the millions of single nucleotide polymorphisms (SNPs) present in the human genome and to pinpoint which of these DNA variations are causative in disease. A key under-studied function of SNPs is their ability to generate or disrupt genomic binding sites for transcription ...

    SBIR Phase I 2011 Department of Health and Human Services
  3. Value Added Product Generation from ARD

    SBC: BLUE PLANET STRATEGIES, LLC            Topic: NIEHS

    DESCRIPTION (provided by applicant): Harmful metals not readily detoxified naturally are discharged from numerous industrial activities and pose lasting environmental hazards requiring expensive remediation efforts. This project targets profitable dilute metal removal and reclamation. Creating an economic driver for metal contamination mitigation improves human health by promoting environmental cl ...

    SBIR Phase I 2011 Department of Health and Human Services
  4. A Novel System for Mass Production of iPS Cells

    SBC: PRIMORIGEN BIOSCIENCES INC.            Topic: NIGMS

    DESCRIPTION (provided by applicant): Primorigen Biosciences LLC SBIR Project Abstract Primorigen will use SBIR funds to develop and validate a microcarrier-based cell culture system for selection, scale-up and feeder-free mass production of iPS cells, based on Primorigen's proprietary pluripotent stem cell attachment factor (StemCadhere ) for direct physical selection and propagation of iPSC. ...

    SBIR Phase I 2011 Department of Health and Human Services
  5. High Throughput Assay for Detecting Protein Modifications in Cell Lysates

    SBC: Bellbrook Labs, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Post translational modifications (PTMs) such as phosphorylation, glycosylation and methylation play a central and ubiquitous role in cellular signal transduction, and the enzymes that catalyze these reactions such as kinases and methyltransferases are the targets of intense drug discovery efforts for virtually every therapeutic area, with the most intense focus ...

    SBIR Phase I 2011 Department of Health and Human Services
  6. An innovative tool for assessment of gait dysfunction in the clinical setting

    SBC: METRIA INNOVATION, INCORPORATED            Topic: NICHD

    DESCRIPTION (provided by applicant): The overall goal of this SBIR Phase I proposal is to establish the measurement reliability and the clinical feasibility of the RGR-GAIT instrumented gait analysis system. Gait dysfunction can dramatically affect a person's ability to perform activities of daily living, and assessment of gait is a critical component of physical therapy practice. Currently, ...

    SBIR Phase I 2011 Department of Health and Human Services
  7. Functional Selection of High Performance Enzymes

    SBC: LUCIGEN CORPORATION            Topic: NHGRI

    DESCRIPTION (provided by applicant): Microfluidic systems are emerging as critically important tools for high throughput cell based analysis for applications including genotyping, sequencing, gene expression analysis, nucleic acid amplification, and diagnostics. Lab-on-a-chip devices that are conventionally designed to perform microchemical reactions in a continuous flow require external component ...

    SBIR Phase I 2011 Department of Health and Human Services
  8. High Fidelity Transcriptome Sequencing Tools

    SBC: LUCIGEN CORPORATION            Topic: NHGRI

    DESCRIPTION (provided by applicant): The regulation of gene expression drives all biological processes. A thorough understanding of the mechanisms governing the patterns of gene expression is necessary to understand the fundamentals of biology and the complexities of cancers and other diseases. The future of research into human disease will be based in next generation sequencing (NGS) of the human ...

    SBIR Phase I 2011 Department of Health and Human Services
  9. A Desktop Assembly and Analysis Pipeline for Next-gen Metagenomic Sequencing

    SBC: DNASTAR, INC.            Topic: NHGRI

    DESCRIPTION (provided by applicant): Over the last decade, bacterial and archaeal communities have been identified in virtually every ecological niche examined, from acid mine drainage to tropospheric clouds to the human body. Understanding the make-up andinteractions within these communities is crucial in understanding how each ecosystem functions. Metagenomics (or community genomics) is the appr ...

    SBIR Phase I 2011 Department of Health and Human Services
  10. Computer Assisted CBT for OCD: A Comprehensive Stepped-Care Approach

    SBC: KOBAK, KENNETH A            Topic: NIMH

    DESCRIPTION (provided by applicant): The need for evidence-based mental health treatments i.e., 'treatment based on the best available science or research evidence , has been stressed from scientific, ethical, and marketing perspectives. While empirical evidence supports both the efficacy and effectiveness of cognitive behavior therapy (CBT) for Obsessive-Compulsive Disorder (OCD), demand for ...

    SBIR Phase I 2011 Department of Health and Human Services
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