Award Data

Computation of the radiative transfer model for a hyperspectral sounder with thousands of spectral channels is very time-consuming. Consequently, operational data assimilation systems can assimilate only a few hundred channels. The radiative transfer model is very suitable for GPU implementation to take advantage of GPU massively parallel computing capability, where radiances at various channels c ...

DESCRIPTION (provided by applicant): Estrogen receptor a (ERa) is the major therapeutic target for breast cancer, and ERa binding at target genes in breast cancer cells is guided by DNA binding pioneer factor proteins such as FoxA1. Although tamoxifen is asuccessful therapeutic for suppressing ER-mediated gene regulation, resistance to tamoxifen occurs in most breast cancer patients within five ye ...

DESCRIPTION (provided by applicant): Non-small cell lung cancer (NSCLC) is among the most common and lethal cancers yet, the current standard of care for advanced stage NSCLC provides only modest improvements in overall survival or quality of life. Thus,there exists a significant unmet need for new effective therapies to treat NSCLC. Herein we describe an innovative new type of antibody drug conj ...

DESCRIPTION (provided by applicant): A critical unmet need in implementing personalized medicine is the ability to sort through the millions of single nucleotide polymorphisms (SNPs) present in the human genome and to pinpoint which of these DNA variations are causative in disease. A key under-studied function of SNPs is their ability to generate or disrupt genomic binding sites for transcription ...

DESCRIPTION (provided by applicant): Harmful metals not readily detoxified naturally are discharged from numerous industrial activities and pose lasting environmental hazards requiring expensive remediation efforts. This project targets profitable dilute metal removal and reclamation. Creating an economic driver for metal contamination mitigation improves human health by promoting environmental cl ...

DESCRIPTION (provided by applicant): Primorigen Biosciences LLC SBIR Project Abstract Primorigen will use SBIR funds to develop and validate a microcarrier-based cell culture system for selection, scale-up and feeder-free mass production of iPS cells, based on Primorigen's proprietary pluripotent stem cell attachment factor (StemCadhere ) for direct physical selection and propagation of iPSC. ...

DESCRIPTION (provided by applicant): Post translational modifications (PTMs) such as phosphorylation, glycosylation and methylation play a central and ubiquitous role in cellular signal transduction, and the enzymes that catalyze these reactions such as kinases and methyltransferases are the targets of intense drug discovery efforts for virtually every therapeutic area, with the most intense focus ...

DESCRIPTION (provided by applicant): We will integrate head and eye movement into a new unified computer access method for people who have high spinal-cord injuries, traumatic brain injuries (TBI), brainstem strokes, and degenerative diseases such as amyotrophic lateral sclerosis (ALS). We hypothesize that combining head and eye movement will improve a user's ability to control a computer by ...

DESCRIPTION (provided by applicant): The overall goal of this SBIR Phase I proposal is to establish the measurement reliability and the clinical feasibility of the RGR-GAIT instrumented gait analysis system. Gait dysfunction can dramatically affect a person's ability to perform activities of daily living, and assessment of gait is a critical component of physical therapy practice. Currently, ...

DESCRIPTION (provided by applicant): Microfluidic systems are emerging as critically important tools for high throughput cell based analysis for applications including genotyping, sequencing, gene expression analysis, nucleic acid amplification, and diagnostics. Lab-on-a-chip devices that are conventionally designed to perform microchemical reactions in a continuous flow require external component ...