Award Data

We propose an innovative Pedestrian Automotive System for Enforcement and Safety (PASES) that combines commercial-off-the-shelf video or camera components and state-of-the-art microwave(radar) systems with sophisticated software that will not only provide more effective enforcement through effective evidentiary information, but will also enable predictive actions based on vehicle and pedestrian be ...

DESCRIPTION (provided by applicant): Crystallization, followed by subsequent structure determination, is a major step in understanding the structure- function relationship of macromolecules. Understanding macromolecule structure has become a key part in the development of new pharmaceuticals, and is a major area of NIH research. Crystallization however is also the rate limiting step, despite techn ...

DESCRIPTION (provided by applicant): Q-Track seeks to develop a Sports Medicine Assessment Tool (SMAT) to provide comprehensive kinematic and physiological data to trainers, coaching staff, and athletes. In addition to the safety benefit of monitoring thevital condition of players in real time, our goal is to develop a fatigue management system. The purpose of this proposal is to integrate kinema ...

DESCRIPTION (provided by applicant): DiscoveryBioMed, Inc. (DBM) has launched an innovative and automation-friendly drug discovery program to screen synthetic organic small molecule collections on differentiated human adipocyte platforms to discover a newclass of therapeutic drugs for type 2 diabetes mellitus (T2DM) and obesity. Differentiated human adipocytes from visceral (central abdominal depo ...

DESCRIPTION (provided by applicant): The proposed effort aims to dramatically enhance the realism of radiation safety training for Emergency Responders, both First Responders, as well as Skilled Support Personnel. The goal is to develop andevaluate realistic dosimetry simulation or Dosimulation tools. These Realistic, Accurate Dosimulation (RAD) tools will be the centerpiece for ...

DESCRIPTION (provided by applicant): The goal of this Phase I SBIR is the pre-clinical development of a novel gene-based delivery system for bevacizumab (anti-VEGF antibody) to treat wet age-related macular degeneration (AMD). The premise is based on: (1)the demonstrated efficacy of monthly intravitreal injections of the monoclonal bevacizumab in treating wet AMD that is accompanied by a high cost ...

DESCRIPTION: Pulmonary drug delivery is increasingly used for both treatment of lung diseases (such as asthma and chronic obstructive pulmonary disease) and in delivering drugs to the systemic circulation. To reach the desired effectiveness and safety oforally/nasally inhaled drugs, appropriate deposition of drugs on targeted region is essential. Due to complex pharmaceutical and physiological fa ...

DESCRIPTION (provided by applicant): Early identification of developmental problems and delays means that interventions can begin sooner and are more effective and less resource-intensive than later interventions, after a problem has festered and worsened.Despite these benefits, statistics indicate that few infants and toddlers actually receive such screenings (AAP 2006). The goal of this Phase I ...

DESCRIPTION (provided by applicant): Brain ischemia is a leading cause of morbidity and mortality in the United States. We seek to develop therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain, anarea of significant unmet medical need. We have shown that ligand activation of the Toll-like receptor (TLR) family of pattern recognition recep ...

DESCRIPTION (provided by applicant): There is no more important target audience for smoking cessation efforts than pregnant women. The goal of this Fast Track project is to establish the scientific and technical feasibility of using an interactive text- and web-based application to support smoking cessation among pregnant women. This project aims to develop the first-ever text message based smokin ...