Award Data

DESCRIPTION provided by applicant The past decade has seen a rapid increase in the application of brain stimulation devices to treat a variety of movement disorders such as Parkinsonandapos s disease PD and other neuropathologies Present noninvasive brain stimulation technologies suffer from fundamental limitations and have yet to reach the level of efficacy of invasive methods such as de ...

DESCRIPTION provided by applicant Errors in the administration of medications to residents of long term care facilities LTCFs threaten resident safety and add significant unnecessary costs to the healthcare system Use of unit dose medications that require LTCF staff to manually sort and assemble specific patient medications times per day can result in error rates as high as with of total errors ha ...

DESCRIPTION provided by applicant The objective of the proposed study is to develop a subcutaneous implant of risperidone which provides consistent therapeutic blood levels of the drug for months The benefits of such product include improved medication adherence the ability to withdraw the medication if needed due to treatment emergent Adverse Effects AEs fewer relapses and improved eff ...

DESCRIPTION provided by applicant Positron Emission Tomography PET is a molecular imaging modality that utilizes radiolabeled molecules andquot probesandquot to target and measure biological processes Basic scientists can use the same probes to examine cells and mice as they do in patients to visualize and characterize the biology of disease monitor its progression and evaluate therapeutic efficac ...

DESCRIPTION provided by applicant NanoNerve is developing a novel diametrically patterned nanofibrous dural substitute for rapid dura mater regeneration following neurosurgical procedures In the US alone neurosurgical procedures are performed annually that require patching of the dura mater to prevent leakage infection and neural damage Currently available dural substitutes include xenogenic colla ...

DESCRIPTION provided by applicant Novel Chronic Volume Microelectrodes for the Broad Neuroscience Community Project Summary Neuroscience researchers studying the nervous system have relied on microelectrode devices to record neural activity for decades Microelectrodes are micro scale structures with exposed conductive regions that are inserted within nervous systems to record the activity of ...

DESCRIPTION provided by applicant NeuroPlay Adventures addresses the need to develop innovative neuroscience educational tools to benefit children in kindergarten through th grade K The goals of this project are to develop mobile apps for tablets and smart phones and a web site that introduces children ages to the brain using music motor and story based activities and to evaluate the effectiveness ...

DESCRIPTION provided by applicant Project Summary Accurate quantification of alcohol and drugs of abuse intoxication in emergency rooms ERs is an important screening step for a precise diagnosis and hence for prompt treatment Some severe emergencies such as traumatic head injury diabetes and stroke can be misdiagnosed in the absence of screening for alcohol and drug intoxication reliable ...

DESCRIPTION Collaborative Drug Discovery Inc CDD will create a novel web based software platform that enables scientists to work together effectively to discover and improve new drug leads by sharing computational predictions based on open source descriptors and models for the first time without needing to reveal underlying chemical structures and biodata It will create the first practical system ...

DESCRIPTION provided by applicant Optogenetic tools for activating and silencing specific neurons embedded within dense brain networks in a temporally precise fashion using light are key to understanding the roles that specific neurons play in behavior neural computation and disease In our Phase I SBIR Ferro Solutions and the Boyden lab at MIT collaborated to develop a fully wirelessly powered and ...