Award Data

DESCRIPTION provided by applicant The past decade has seen a rapid increase in the application of brain stimulation devices to treat a variety of movement disorders such as Parkinsonandapos s disease PD and other neuropathologies Present noninvasive brain stimulation technologies suffer from fundamental limitations and have yet to reach the level of efficacy of invasive methods such as de ...

DESCRIPTION provided by applicant Errors in the administration of medications to residents of long term care facilities LTCFs threaten resident safety and add significant unnecessary costs to the healthcare system Use of unit dose medications that require LTCF staff to manually sort and assemble specific patient medications times per day can result in error rates as high as with of total errors ha ...

DESCRIPTION provided by applicant Optogenetic tools for activating and silencing specific neurons embedded within dense brain networks in a temporally precise fashion using light are key to understanding the roles that specific neurons play in behavior neural computation and disease In our Phase I SBIR Ferro Solutions and the Boyden lab at MIT collaborated to develop a fully wirelessly powered and ...

DESCRIPTION Undesired platelet activation can be result of many common pathologies or interventions Arterial thrombosis and the acute ischemic events that follow such as myocardial infarction and stroke are among the leading causes of death incapacitation and rising health care costs in the developed world Therefore antiplatelet drugs have significant market share and clinical importance ...

DESCRIPTION provided by applicant The goal of this project is to develop a therapeutic acting specifically against Helicobacter pylori the causative agent of peptic ulcer and gastric carcinoma Roughly every other person carries the pathogen and there are an estimated cases annually of active infection in the US The currently used triple therapy is a combination of a proton pump inhibitor and broad ...

DESCRIPTION provided by applicant The overall goal of this project is to discover novel antibiotics to combat important drug resistant pathogens We are running out of treatment options for pathogens such as S aureus MRSA vancomycin resistant Enterococci VRE multidrug resistant P aeruginosa A baumannii ESBL and New Delhi metallo b lactamase producing Enterobacteriaceae and M tuberculosis Only novel ...

Physical Sciences Inc. (PSI) proposes to develop a sensor system based on an innovative approach for liquid contaminant detection and identification on operationally-relevant surfaces. The proposed system will provide a sensitive (1 mg/m2 objective, 500 mg/m2 threshold), stand-off (

The objective of this proposal is to develop and demonstrate the feasibility of high-intensity focused ultrasound (HIFU) applications for donor explosive-free detonation of insensitive munitions (IM) and insensitive high explosives (IHE). General Technology System's (GTS) solution, termed the Zero-Explosive Ultrasound Standoff (ZEUS) detonation system, will provide a low-cost, covert, ultra-p ...

Current CB garment systems such as Joint Services Lightweight Integrated Suit technology (JSLIST) and Joint Service Lightweight Integrated Suit Technology (JSLIST) Chemical Biological Coverall for combat vehicle crewmen (JC3) use a layer of absorptive carbon and selectively permeable membranes respectively offering protection against chemical and biological threats. It is not uncommon for garments ...

Mitigation and recovery from an attack with a chemical or biological agent remains an important challenge for the US Defense and Homeland Security. Solicitation topic CBD13-101 envisions a multifunctional sequestration coating that once applied to a contaminated surface will sequester the contaminating agent, disclose the location of agent contamination, detoxify the agent and be removable so as ...