Award Data

Many protein-based drugs have limited efficacy due to a short half-life or require intravenous delivery because of low bioavailability when given subcutaneously. Extend Biosciences is developing proprietary carrier molecules that will allow proteins to access a transport pathway for efficient delivery to the vascular space and then maintain a sustained presence in circulation. This would be of par ...

Protein manufacturing is of paramount importance to chemical and biological defense applications. High-throughput protein purification is a critical need for rapidly scaling the target protein product. Existing purification methods primarly rely on synthetic-resin based chromatography, which is time-consuming, labor-intensive, expensive, and consequently, ill-suited for developing rapid countermea ...

Busek Co. Inc. and Ionic Research Technologies, LLC propose to develop a novel carbon dioxide and water removal technology using ionic liquids for closed circuit self-contained breathing apparatus that will extend its operating lifetime, while simultaneously reducing overall weight and logistic burden. Ionic liquids offer unique characteristics including high capacity CO2 capture, tunable gas sel ...

Safe and efficient air ionization and filtration technology compatible to biodefense applications is of paramount importance. Current ionization methods are energy-intensive, costly, prone to ozone generation, or inefficient, and consequently ill-suited for building protection applications. To overcome these issues, we propose to develop and demonstrate a novel bioaerosol ionization and collection ...

In the event of an intentional or accidental release of ionizing radiation, it will be critical to have rapid triage assessment tools to evaluate the health of mission-critical personnel and to make effective use of available medical and emergency resources. However, assessment of whole body radiation dosage is challenging and established methods rely on visual manifestations, blood sampling and s ...

Highway-rail crossing, at which there is an unusually abrupt change in the level of the road's surface as it crosses the tracks, pose a risk of low ground clearance vehicles becoming stuck on the tracks. Advanced Technology and Research Corporation (ATR) proposes to develop an active detection and advance warning system. The system has three major functional componenets: measurement, decision, ...

The problem of low ground clearance vehicles being stuck at tracks of highway-rail grade crossings (HRGC) poses a severe safety risk. Vehicles with long wheelbases and low ground clearance are more likely to be stuck on high-profile HRGCs. Currently there is no commercially available automated system that detects and computes the necessary critical dimensions of low ground clearance vehicles (LGCV ...

We propose an innovative Pedestrian Automotive System for Enforcement and Safety (PASES) that combines commercial-off-the-shelf video or camera components and state-of-the-art microwave(radar) systems with sophisticated software that will not only provide more effective enforcement through effective evidentiary information, but will also enable predictive actions based on vehicle and pedestrian be ...

This is a supplemental Phase II proposal submitted to DOT for additional funding and performance period extension of the on-going DOT Phase II project (contract # DTRT57-10-C-10027). The overall objective of the Supplemental Phase II effort is to complete the development of the sensor system capable of continuously monitoring the integrity of bridge structures, conduct field operation validation ...

Image processing methods have been studied and implemented for the vehicle classification over the past decades. The most dominant approach is the use of vehicle dimension, which requires complex processes of sensor calibration as the vehicle dimensions shown in the imagery are heavily dependent on the camera’s field of view. In general, video systems have physical disadvantages related to the ...