Award Data

We propose an innovative Pedestrian Automotive System for Enforcement and Safety (PASES) that combines commercial-off-the-shelf video or camera components and state-of-the-art microwave(radar) systems with sophisticated software that will not only provide more effective enforcement through effective evidentiary information, but will also enable predictive actions based on vehicle and pedestrian be ...

Image processing methods have been studied and implemented for the vehicle classification over the past decades. The most dominant approach is the use of vehicle dimension, which requires complex processes of sensor calibration as the vehicle dimensions shown in the imagery are heavily dependent on the camera’s field of view. In general, video systems have physical disadvantages related to the ...

To assist with the National Geodetic Survey’s federal mandate to provide accurate positioning—including heights—to all federal non-military mapping activities in the USA, Aurora Flight Sciences proposes to integrate a gravimetry payload on a unmanned aerial system (UAS). Potential options include using either an unmanned aerial vehicle (UAV) or an optionally piloted aircraft (OPA). An OPA ...

This topic requires the capability for enabling high sensitivity/high precision measurements of calcium concentrates in seawater. This proposal aims to demonstrate the feasibility of a novel high sensitive nanosensor that can be used to determine very low concentrations of calcium in seawater in the presence of a large background calcium concentration. The sensor approach uses the benefits of nano ...

DESCRIPTION (provided by applicant): Alzheimer's disease (AD) occurs in one out of eight Americans of age 65 and affects 43% of the elderly over 85. Current FDA-approved drugs only provide symptomatic relief of AD. There is a pressing need to discover newdisease-modifying medications. AD is multifactorial in origin and progression. A drug attenuating several underlying factors is a preferred ...

DESCRIPTION (provided by applicant): Even though the association of -amyloid peptide (A ) deposition and Alzheimer's Disease (AD) underpins the major hypothesis for disease progression and possibly causation and several drugs addressing the formation or removal of -amyloid plaques have entered clinical trials, no effective therapy exists to date for AD. This reality calls for new targets th ...

DESCRIPTION (provided by applicant): In the United States, around 76,250 new cases of melanoma and 9,180 melanoma-related deaths are predicted for 2012. With the therapeutic options currently available, metastatic melanoma patients face the bleak prospectof at best, 10 month's survival and a one-in-ten chance of surviving for 10 years. Surgery and radiation therapy are the mainstay of treatme ...

DESCRIPTION (provided by applicant): End-stage liver disease claims about 30,000 lives in the US. Many patients become too ill to tolerate liver transplantation, and even if transplantation were indicated, there is a severe shortage of viable donor organsand only 28% of the wait-listed patients receive transplants. Development and translational studies with novel alternatives to organ transplanta ...

DESCRIPTION (provided by applicant): Chronic refractory, or non-healing, wounds or ulcerations of the extremities represent a major medical condition affecting millions of patients. A chronic wound is defined as a wound that does not show signs of significant healing, or progresses, after use of topical/surgical treatment measures for six months. Non-healing wounds affect 6.5 million patients, aff ...

DESCRIPTION (provided by applicant): Pharmacological Targeting of Endothelial Dysfunction in Atherogenesis Cardiovascular disease is the leading cause of morbidity and mortality in the United States and is an emerging epidemic world-wide. In particular, atherosclerosis is a life-threatening disease strongly associated with risk factors such as elevated cholesterol levels, high blood pressure and d ...