Award Data

Autonomous inspection systems are necessary to increase awareness of track safety and maintenance issues. However, electrical power for these systems is not available under freight railway vehicles. Mainstream Engineering (MEC) proposes development of a small-scale diesel generator with an integrated starter-alternator (ISA) and automated battery charging circuit for this application. The proposed ...

During the Phase I SBIR Effort, Mainstream demonstrated a unique vehicle monitoring system (VMS) for tractor trailer applications. The development was driven by the need to easily store, retrieve, and transfer key trailer parameters to the tractor and the need to electronically transfer key driver, tractor, and trailer information to roadside inspectors and maintenance personnel. In Phase I, we ...

DESCRIPTION (provided by applicant): While there is no doubt smoking is a direct causative factor underlying the development of lung cancer, not every smoker develops lung cancer. In fact, only 10-15% of smokers develop this disease, indicating that otherfactors make certain individuals more susceptible to cancer. A number of single nucleotide polymorphisms are known to correlate with the developm ...

DESCRIPTION (provided by applicant): According to the American Cancer Society, half of all men and one-third of all women in the United States will develop cancer in their lifetime. While chemotherapy has dramatically improved the survival rate of cancer patients, it comes at the cost of severe toxicities and in some cases poor response rates. In order to address these shortcomings, equal investme ...

DESCRIPTION (provided by applicant): Preeclampsia, a hypertensive disorder of pregnancy, is a leading cause of maternal and neonatal morbidity and mortality around the world, responsible for approximately 76,000 maternal and 500,000 infant deaths per year.As a heterogeneous and poorly understood disorder, its pathogenesis and possible treatments are an area of active research. While the majority o ...

DESCRIPTION (provided by applicant): Diabetes mellitus (DM) leads to a 3-4 fold higher risk of experiencing ischemic stroke. In addition, DM stroke patients are more prone to develop more and earlier white matter (WM) high-intensity lesions than non DM stroke patients. Treatment of stroke with tissue plasminogen activator (rtPA) at 2-3 hours after stroke decreases lesion volume in non-DM rats. How ...

DESCRIPTION (provided by applicant): Multiple Sclerosis (MS) is an autoimmune disease that affects the central nervous system (CNS) and results in neurological and clinical disability i number of adults in the US. Leukocyte infiltration and plaques of demyelination in the brain and spinal cord of patients are a hallmark of MS. Currently, there is no cure and few therapies for this debilitating ...

DESCRIPTION (provided by applicant): Lung cancer is the leading cause of cancer deaths worldwide. The high mortality is in part due to the lack of good tests for early detection and treatment. Our technology diagnoses the presence of cancer via analysis ofthe specific fingerprint of volatile organic molecules produced by tumor metabolism, out- gassed from tumor tissue to blood and excreted in urin ...

DESCRIPTION (provided by applicant): The majority of multiple myeloma (MM) patients will initially respond to standard chemotherapy. However, eventually relapse of the disease, associated with a multi-drug resistant phenotype, contributes to poor clinicaloutcomes. Modulation Therapeutics is dedicated towards developing strategies for targeting cancers like MM that home or metastasize to the bone. ...

DESCRIPTION (provided by applicant): This project aims to develop a device capable of acquiring transient and steady state auditory evoked potenlatials (AEPs) simultaneously using an efficient and advanced processing technique. The proposed technique willbe implemented as a software module on Intelligent Hearing Systems' (IHS) evoked potential system platform. Auditory Transient Responses (AT ...