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The Award database is continually updated throughout the year. As a result, data for FY20 is not expected to be complete until September, 2021.

  1. Development of Membrane Anchored Cytokines as Novel Vaccine Adjuvants for the Elderly

    SBC: METACLIPSE THERAPEUTICS CORPORATION            Topic: NIAID

    lnterleukinILand granulocyte macrophage colony stimulating factorGM CSFare endogenous immune activatorsEarlier studies using soluble ILand GM CSF as vaccine adjuvants were unsuccessful due to toxicity or suboptimal responseWe developed versions of ILand GM CSF with a glycosylated phosphatidylinositolGPIanchor added at the carboxyl terminusallowing incorporation into lipid bilayers such as in influ ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Creating Antibodies to Enable the Study of Mycobacterium Tuberculosis Infections in Guinea Pigs

    SBC: GlycoScientific, L.L.C.            Topic: NIAID

    Tuberculosis is a persistent infectious disease that threatens the health of people and numerous mammalian species throughout the worldMonitoring of Mycobacterium tuberculosisMtbinfections in animal models has often relied on host mortalitybacterial loadsand qualitative assessment of pathology at necropsyThese are blunt toolslargely unrelated to the markers used for diagnosis and epidemiological s ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Toward the Development of a Protein: Non-protein Macromolecular Adjuvants

    SBC: Hafion LLC            Topic: NIAID

    An existing problem being faced in the development of new vaccines is the need for targeting bacterial infections that occur at mucosal sites such as the upper airway and the gastrointestinal tractOvercoming this problem will require the use of novel vaccine formulations andin particularthe use of novel immune enhancing agentsadjuvantsthat promote immune responses that are effective at mucosal sit ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Enzyme Replacement Therapy for Complement C2-Deficiency

    SBC: Nectagen, Inc.            Topic: NIAID

    The goal of this Phase I SBIR project is to develop a scalable method of Cpurification for use in Creplacement therapy based on a novel immunoaffinity chromatography resinDeficiency of complement CC Dis reported to be the most common hereditary defect among complement components with a prevalence ofPatients with homozygous complete deficiency suffer from recurring pyrogenic infections with encapsu ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Novel sanitizer/disinfectants against viral infections with long-lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    AbstractNorovirus is the most common cause of acute gastroenteritis in the United Statesassociated annually withmillion illnesseshospitalizations anddeathsUS CDCOverview about NorovirusNorovirus is one of the nonenveloped viruses that are resistant to alcohol sanitizationAccording to US CDC Guidelines for the Prevention and Control of Norovirus Gastroenteritis Outbreaks in Healthcare Settingsthe p ...

    STTR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  6. A Microscale Platform for Augmentation of Cell Transduction (MPACT) to Enhance Ex Vivo Gene Transfer

    SBC: EXPRESSION THERAPEUTICS LLC            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT Recent advances in clinical gene therapy highlight the need for improved lentiviral vectorLVand adenoassociated viralAAVvector manufacture and utilization efficiencies for enhanced therapeutics outcomesExpression Therapeutics in collaboration with Emory University are developing a microfluidicFluidictechnology based solution that overcomes the mass transport and diffusion ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  7. The Diagnostic Utility of the in-vitro "Provoked" D dimer test in patients with suspected pulmonary embolism

    SBC: AUGdimer LLC            Topic: NHLBI

    Project SummaryThe D Dimer assay is the current diagnostic standard to exclude patients of VTE due to its high sensitivityHoweverD Dimer levels are commonly elevated in patients without thromboembolismleading to poor specificity and poor positive predictive valuePPVDue to the lack of a robust diagnostic tool for VTEwe propose a novel advancement upon current DDimer testing which improves specifici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Chemoenzymatic synthesis of a human milk oligosaccharide array for discovery of therapeutic leads

    SBC: VIAMUNE, INC.            Topic: 300

    Project SummaryAbstractHuman milk oligosaccharidesHMOsare the third largest component of breast milk and have been described to convey developmental benefits to the newbornHMOs may comprise a wealth of untapped therapeutic opportunities as this unique class of molecules can interact withand thereby potentially modulatemediators of inflammationUnfortunatelyinvestigation into the therapeutic utility ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Diagnostic Test for Detecting Recent Seizures in Epilepsy Patients

    SBC: Sceptor Industries, Inc.            Topic: 106

    Project SummaryAbstractEpilepsy affects approximatelyof the world populationtotaling andgtmillion patientsWhile anti epileptic drugAEDtreatment is successful in many patientsof patients continue to experience seizures causing physicians to adjust change medications or other treatment parametersCurrent diagnostic tools are incapable of differentiating between patients experiencing a recent seizure ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  10. A Tissue Support Structure (Macular O-Rings) for Reconstructing, Translocating or Transplanting Three-Dimensional Submacular Tissue Organoids in Age Related Macular Degeneration (AMD)

    SBC: iMacular Regeneration LLC            Topic: NEI

    Project Summary Abstract Age related macular degenerationAMDis a leading form of irreversible blindnessiMacular Regeneration LLCiMac Regenwill introduce a novel tissue support structuremacular O rings or MORsmade from a biocompatibleimplantable materialnitinol or nickel titanium alloyThe surgical deviceMORwill be tested both ex vivo and in vivo for proof of concept in this phase I STTR studyThe de ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
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