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ALZHEIMER'S DISEASE (AD), A LEADING HEALTH PROBLEM FOR THIS COUNTRY, AFFECTS 5 TO L0 PERCENT OF THOSE OVER 65. BY THE YEAR 2000, THIS AGING POPULATION WILL DOUBLE. A TEST PERMITTING A DEFINITIVE AND EARLY DIAGNOSIS OF AD IS GREATLY NEEDED. WE SEEK TO DEVELOP SUCH A DIAGNOSTIC TEST USING MABS IT HAS RAISED TO A MODIFIED FORM OF ALX. IN PHASE I STUDY, ART WILL CHARACTERIZE ITS MABS, DESIGN A PILOT I ...

USING AN EXISTING INTELLIGENT TUTORING SYSTEM (ITS), PROJECT MEMBERS WILL CREATE THE SPECIFICATIONS FOR A STUDENT MODEL THAT CAN BE USED TO DESIGN AN ADAPTIVE TESTING SYSTEM. THIS TESTING SYSTEM WILL BE ABLE TO IDENTIFY OR DIAGNOSE STUDENT ERRORS BY ANALYZING THE STUDENT'S PERFORMANCE USING SEVERAL DIFFERENT FACTORS. THE PROJECT WILL ALSO INVESTIGATE THE POTENTIAL FOR DEVELOPING A TASK GENERATION ...

REPORTS ON ACCIDENTS OF MODERN MILITARY FIGHTERS INCREASINGLY IMPLICATE PILOT DISORIENTATION AS A FACTOR. WHILE SPATIAL DISORIENTATION OF PILOTS HAS BEEN A PROBLEM IN AVIATION SINCE THE BEGINNINGS OF INSTRUMENT FLIGHT, IT HAS BEEN A GROWING CONCERN IN HIGH PERFORMANCE JET COCKPITS. THE HEAD-UP DISPLAY (HUD) HAS BEEN IMPLICATED AS A CONTRIBUTOR TO DISORIENTATION. RECENT RESEARCH HAS DEVELOPED SEVER ...

DURING THE LAST 20 YEARS, ALLOGRAFT HEART VALVE TRANSPLANTATION IN THE UNITED STATES HAS INCREASED FROM ABOUT 50 TO 2,000 PER ANNUM. BECAUSE OF THIS INCREASED DEMAND, PARTICULARLY FOR PEDIATRIC CASES, UTILIZATION OF THESE CRYOPRESERVED HEART VALVES IS NOW LIMITED BY THE SUPPLY OF DONATED HUMAN HEARTS. THE OBJECTIVE IS TO CONVERT XENOGRAFT HEART VALVES INTO ALLOGRAFTS IN AN ATTEMPT TO RESOLVE THIS ...

THIS STUDY FOCUSES ON THE USE OF ANTIFREEZE PEPTIDES IN THE DEVELOPMENT OF AN IMPROVED METHOD FOR CRYOPRESERVATION OF BONE MARROW PROGENITOR CELLS. RECOMBINANT ANTIFREEZE PEPTIDES HAVE BEEN FOUND TO INHIBIT MIGRATORY RECRYSTALIZATION DURING THAWING OF ERYTHROCYTES AND TO PERMIT REDUCTION IN DIMETHYLSULFOXIDE CONCENTRATIONS IN CRYOPRESERVATION OF THE LEUKEMIC CELL LINE KG-LA. THE OBJECTIVE OF THIS ...

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THE PURPOSES OF THIS PROJECT ARE TO: A) DEVELOP A SERIES OF COOPERATIVE STRATEGIES THAT TEACHERS CAN TEACH TO THEIR STUDENTS AS THEY WORK TOGETHER WITHIN COOPERATIVE GROUP STRUCTURES IN MAINSTREAM CLASSROOMS; AND B) DEVELOP AND EMPIRICALLY VALIDATE THE MATERIALS AND PROCEDURES THAT ARE NECESSARY FOR EFFECTIVELY AND EFFICIENTLY PRODUCING MASTERY OF THOSE STRATEGIES. THE PROGRAM WILL BE FIELD TESTED ...

THE PROBLEM TO BE ADDRESSED INVOLVES A WELL DOCUMENTED CONCERN IN THE FIELD OF INTRAVENOUS THERAPY AND INVASIVE HEMODYNAMIC MONITORING. FLUID FILLED CATHETERS, WHILE INFUSING FLUIDS INTO THE BLOOD VESSELS, CAN CARRY BACTERIA INTO A PATIENT'S BLOOD, LEADING TO NOSOCOMIAL BACTEREMIAS. THE PART OF THE PROBLEM THIS PROJECT DEALS WITH IS STOPCOCK CONTAMINATION. THE STOPCOCK IS A THREE-WAY VALVE DEVICE ...

NOVA TECHNOLOGY, INC. IS INVESTIGATING THE USE OF AN OPTICAL SETUP SIMILAR TO A TWYMAN-GREEN INTERFEROMETER, A LASER BEAM TO ILLUMINATE A MICROSCOPE SPECIMEN AND A REFERENCE SURFACE, IN THE SCATTERED LIGHT FROM THE SPECIMEN IS MIXED WITH THE SCATTERED LIGHT FROM THE REFERENCE SURFACEAT THE IMAGE PLANE OF THE MICROSCOPE. BY MONITORING THE SPECKLE INTENSITY WITH A CCD ARRAY, THE PHASE CHANGE IN SPEC ...

ALTERATIONS IN SURFACE CARBOHYDRATES IN GLYCOLIPIDS AND GLYCOPROTEINS OF TUMOR CELLS RELATIVE TO NORMAL CELLS IS A COMMON FEATURE OF MALIGNANT DISEASES. IMMUNOSTAINING PROCEDURES DEVELOPED FOR DETECTING GLYCOLIPID ANTIGENS WITH TUMOR-SPECIFIC ANTIBODIES REPRESENT IMPORTANT NEW TECHNIQUESFOR IMMUNODIAGNOSTICS AND IMMUNOTHERAPEUTICS. THE CURRENT METHODS FOR THESE DIAGNOSTIC TESTS RELY ON REAGENTS TH ...