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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. A nanotechnology approach to higher brain penetrance and sustained brain delivery of intranasal oxytocin

    SBC: DD Therapeutics, LLC            Topic: NIDA

    Psychostimulant abuse is a significant public health problemwithmillion Americans reporting cocaine use andmillion reporting methamphetamine useCurrentlythere are no FDA approved pharmacotherapies to treat stimulant dependencePrevious cocaine medications development efforts have focused on small molecule drugs as they can readily enter the brainThe lack of brain penetrance by large molecules was s ...

    STTR Phase I 2018 Department of Health and Human Services
  2. Compact Navigation System for CT-guided Needle Interventions

    SBC: 3T Technologies, LLC            Topic: NCI

    SummaryThe goal of this proposal is to develop and validate a cost effectiveeasy to use and fully integrated navigation system for needle placement during CT image guided cancer diagnosis and treatmentBackgroundAccurate diagnostic and therapeutic interventions depend on accurate needle insertionwhich is subject to the physicianandapos s visuospatial ability and experienceand could be difficult in ...

    STTR Phase I 2018 Department of Health and Human Services
  3. OC-Go: Facilitating fidelity and dissemination of evidence based treatment for childhood OCD via an interactive crowd-sourced patient-provider tool

    SBC: VIRTUALLY BETTER INC            Topic: 104

    The long term objective of this project is to leverage mobile technologies and crowdsourcing to create a new paradigm of evidence based treatment delivery and disseminationas current methods are often insufficientThe project seeks to refine and assess OC Goa HIPAA compliant web based clinician portal and patient side mobile application designed to increase patient adherence to evidence based treat ...

    STTR Phase II 2018 Department of Health and Human Services
  4. New RSV Vaccines with Improved Safety and Efficacy

    SBC: ADVAC LLC            Topic: NIAID

    Project Summary Respiratory syncytial virusRSVinfectsmillion people and causes substantial mortality annually worldwideThere is no licensed RSV vaccineClinical trials of alum adjuvantedformalin inactivated whole RSVFI RSVvaccine caused vaccine enhanced respiratory disease during epidemic seasonwhich resulted in hospitalizations and two deathsIt is essential that an effective and safe RSV vaccine n ...

    STTR Phase I 2018 Department of Health and Human Services
  5. Detection and Staging of Liver Fibrosis by Precise MRI (pMRI)

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: NIAAA

    Abstract Chronic liver injury due to alcoholmetabolic dysfunctionviral hepatitisor autoimmune disease results in liver inflammation and fibrosisLiver fibrosis will progress to cirrhosis which is estimated to affectof the world s populationThe major clinical consequences of cirrhosis are liver failure and hepatocellular carcinomaHCCboth of which increase the risk of deathAlcoholic liver diseaseALDi ...

    STTR Phase II 2018 Department of Health and Human Services
  6. Development of a protein drug for pancreatic cancer treatment

    SBC: ProDa BioTech L.L.C.            Topic: NCI

    Abstract Pancreatic cancers are devastating diseases with five year survival rate less thanCurrentlythere is no effective treatment for advanced diseaseOne major barrier to efficacy of anti tumor therapeutics is the dense desmoplastic stromal responseEvidence suggests that cancer associated pancreatic stellate cellsCAPaSCproduce the stromal collagenThe ECM laid down by CAPaSC is considered to be o ...

    STTR Phase II 2018 Department of Health and Human Services
  7. Preclinical assessment of the GluN2B inhibitor clinical candidate NP10679 as a medication to prevent opiate abuse relapse

    SBC: NEUROP, INC.            Topic: NIDA

    Abstract The current status of opiate abuse in the US has been characterized as arapidly evolving publichealth crisisrequiring the need for new treatments to address the problemPersistent relapse toaddictive drug use is a significant challenge to addiction therapyMedications targeting theneurobiology underlying relapse offer additional avenues for treatmentGlutamate signaling iscritically involved ...

    STTR Phase I 2018 Department of Health and Human Services
  8. STTR Phase I: Directional minimally invasive microwave antenna for precise spatial control of thermal ablation

    SBC: Precision Microwave Inc.            Topic: BM

    The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project include development of a commercial proof-of-concept percutaneous directional microwave ablation (MWA) applicator which may provide medical practitioners a new approach for treating cancer. In clinical use, a directional MWA applicator will facilitate both procedural and technical simplification of MW ...

    STTR Phase I 2018 National Science Foundation
  9. STTR Phase I: Dual-pH Water Splitting Device Comprising Earth-Abundant Electrocatalysts

    SBC: Avium, LLC            Topic: CT

    This Small Business Innovation Research Phase I project will assess the commercial viability of using new non-precious metal catalysts to produce hydrogen by splitting water. Electrolyzers made with these new catalysts have the potential to deliver higher efficiencies and lower capital costs than currently available systems. The market for hydrogen today is $115 billion per year. Currently, hydrog ...

    STTR Phase I 2018 National Science Foundation
  10. Novel sanitizer against viral infections with long lasting effect

    SBC: CAMELLIX, LLC            Topic: NIAID

    Project Summary Abstract Despite mandatory use of hand sanitizer on cruise ships there are reported cruise ship onboard norovirus outbreaks in exceeded the number of norovirus outbreaks outbreaks onboard cruise ships in One of the problems of currently available alcohol based hand sanitizer is that alcohol evaporates in less than seconds after each application to a surface ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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