Award Data

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project is intimately tied to the significant increase in transistor density that semiconductors have experienced over the past few decades. This has enabled many technological advances ranging from high performance servers to Internet of Things devices. Still with every advance in chip technology the ...

The broader impact/commercial potential of this project is a breakthrough innovation that will revolutionize preclinical drug testing, provide valuable information for the first-in-human clinical trials, rescue drugs, decrease time to optimize therapies, and reduce the incidence of safety hazards and adverse reactions. Clinical-Trials-on-a-Chip will serve as the pioneering platform for predictive ...

The broader impact/commercial potential of this Small Business Technology Transfer (STTR) project is to establish a bio-based manufacturing process for the production of the commodity chemical 4-hydroxycoumarin (4-HC) in an economical and renewable way. 4-HC is a direct synthetic precursor used to manufacture widely used oral anticoagulants, such as warfarin, acenocoumarol, and phenprocoumon. In a ...

The broader impact/commercial potential of this Small Business Innovation Research Phase II project is to facilitate the commercialization of low fat replacement EPG technology to help solve some of the largest obesity and related health issues facing the US while providing a patentable new additive platform for the $600 billion food industry. With high caloric density foods being the primary caus ...

DESCRIPTION provided by applicant Inhibikase Therapeutics is a clinical stage biopharmaceutical company that has developed a host targeted mechanism of action to treat AIDS related and drug induced progressive multifocal leukoencephalopathy PML PML is a demyelinating disease of the central nervous system and was rarely seen clinically until the era of the HIV epidemic began in the mid s During the ...

This SBIR Phase II project focuses on developing an accessible educational platform that combines mobile interfaces and adaptive educational tablet applications (Apps) to support the needs of children with special needs. Tablet devices are known to provide an interactive experience that has revolutionized learning for children. Unfortunately, while these tablet devices are intuitive to utilize and ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is in advanced manufacturing. This project will develop a low cost, small-footprint high-resolution nanomanufacturing platform for building optical devices that are traditionally manufactured using cleanroom microlithography. Compared with modern cleanroom approaches that require significantl ...

DESCRIPTION provided by applicant Bacterial related marginal decay is the top reason for failure and retreatment of resin based composite restorations RBCs Retreatment of these restorations costs both the patients and insurance companies billions of dollars per year The weak point of the system is the zone known as the hybrid layer where the adhesive bonds the RBC to the dentin There are ...

DESCRIPTION provided by applicant The objective of this Phase I STTR research is to develop and test osteoinductive lumbar spinal fusion implant prototypes made using materials technology developments discovered by the PI at the University of Kansas In preliminary work lower impedance piezoelectric composite materials that generate power for direct current DC electrical stimulation applica ...

DESCRIPTION provided by applicant Epilepsy is the th most common neurological disorder with in people developing epilepsy the occurrence of more than one unprovoked seizure at some point in their lifetime Unfortunately of all patients have intractable medication resistant epilepsy Thus new anti epileptic drugs AEDs that target alternative mechanisms of action are needed ...