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ANTI-IDIOTYPIC MONOCLONAL ANTIBODY (AIMA) THERAPY HAS CURATIVE POTENTIAL FOR LOW-GRADE B-CELL LYMPHOMAS THROUGH IMMUNOLOGIC DOWN REGULATION OF THE MALIGNANT IDIOTYPIC CLONE AS WELL AS ANTIBODY-DEPENDENT CELL MEDIATED CYTOTOXICITY. PRODUCTION OF AIMA IS PATIENT-SPECIFIC AND LABOR INTENSIVE REQUIRING A MEDIAN OF 912 MONTHS UTILIZING THE CLASSICAL MURINE MYELOMA $ HUMAN B-CELL HYBRIDOMA APPROACH. THE ...

ENERGY INTERNATIONAL PROPOSES TO DEVELOP A COMPREHENSIVE COMPUTER SIMULATION TECHNIQUE TO EVALUATE THE EROSIVE CHARACTERISTICS OF SLURRY JET PUMP SYSTEMS. THE COMPUTER CODE SOLVES A SET OF COUPLED GOVERNING EQUATIONS FOR FLUID MECHANICS, PARTICLE DYNAMICS AND EROSION KINEMATICS. THE CODE WILL BE USED TO VERIFY THE IMPROVED ANTI-EROSION PERFORMANCE OF AN INNOVATIVE SLURRY JET PUMP DEVELOPED BY ENER ...

ACUTE THROMBOSES OF ARTERIES ARE USUALLY A MEDICAL EMERGENCY. THE LONG-TERM OBJECTIVE OF THIS PROJECT IS TO DEVELOP A PULSED FLUIDJET SYSTEM FOR INTRAVASCULAR USE TO HYDRAULICALLY REMOVE CLOTS AND DEBRIS FROM OCCLUDED ARTERIES VIA SMALL CALIBER ANGIOGRAPHIC CATHETERS. WE PROPOSE A PULSED FLUID IRRIGATION SYSTEM COMBINED WITH ASPIRATION THROUGH THE LUMEN OF THE CATHETER. A SPECIALIZED PUMP, CATHETE ...

VISCOUS AERODYNAMIC DRAG ACCOUNTS FOR ABOUT HALF OF THE TOTAL DRAG ON COMMERCIAL AIRCRAFT AT SUBSONIC CRUISE CONDITIONS. TWO AVENUES ARE AVAILABLE TO ACHIEVE SUBSTANIALDRAG REDUCTION: EITHER LAMINAR FLOW CONTROL OR TURBULENCE MANIPULATION. THIS PROPOSAL CONCERNS THE LATTER APPROACH. A NEW TECHNIQUE TO REDUCE SKIN FRICTION DRAG IN A TURBULENT BOUNDARY LAYER IS PROPOSED. THE TECHNIQUE COMBINES THE B ...

THE DEVELOPMENT OF A PROXIMITY SENSOR FOR USE IN AUTOMATED ASSEMBLY AND INSPECTION OPERATIONS IS PROPOSED. A TWO-DIMENSIONAL ARRAY OF SMALL CAPACITIVE PROXIMITY SENSORS DETECTS THE DISTANCE BETWEEN EACH SENSOR TIP AND THE TARGET OBJECT. WHEN OPERATING AT A CLOSE DISTANCE TO THE OBJECT (LESS THAN 10 MM), AN IMAGE OF THE SURFACE CONTOUR IS OBTAINED IN ADDITION TO THE DISTANCE INFORAMTION. THE SENSIN ...

HIGH-PRESSURE WATERJET IS ONE OF SEVERAL NEW METHODS FOR CUTTING MATERIALS DEVELOPED DURING THE LAST DECADE. CURRENTLY IT IS USED, AT STATIC WATER PRESSURE UP TO 60,000 PSI, TO CUT A WIDE VARIETY OF SOFT AND MEDIUM-HARD MATERIALS IN FACTORIES; IT HAS BEEN EVALUATED FOR GEOTECHNICAL APPLICATIONS WITH VERY LIMITED SUCCESS. THIS RESEARCH CONCERNS THE USE OF ABRASIVE-ENTRAINED WATERJET FOR CUTTING AND ...

THE MECHANISMS OF WOUND HEALING AND TISSUE REPAIR IN HUMANS ARE OFTEN IMPAIRED IN THE ELDERLY, IN CANCER PATIENTS AFTER CHEMOTHERAPY AND RADIATION TREATMENTS, IN PERSONS WITH DIABETES OR POORLY HEALING FISTULAS, GHL-CU (GLYCYL-1-HISTIDYL-1-LYSINE:COPPER(II)) IS A GROWTH FACTOR PRESENT IN HUMAN BLOOD THAT APPEARS TO FUNCTION AS A WOUND-HEALING AND ANTITRAUMA HORMONE. GHL-CU ACCELERATES THE HEALING ...

A SERIES OF FUCOSYLATED GLYCOSPHINGOLIPIDS WITH THE ""X'' DETERMINANT (GAL 1 4FUC 1 3GLCNAC) HAVE BEEN SHOWN TO ACCUMULATE IN HUMAN COLONIC AND LIVER ADENOCARCINOMA AND ARE VIRTUALLY ABSENT IN NORMAL COLONIC MUCOSA AND NORMAL LIVER TISSUE. HOWEVER, SMALL QUANTITIES OF FUCOLIPIDS WITH THE ""X'' DETERMINANT (LEX) ARE DISTRIBUTED IN NORMAL TISSUES, SUCH AS GASTRIC EPITHELIA AND KIDNEY TUBULES. PRELIM ...

EASIER TO CONJUGATE TO ANTIBODIES WITH HIGHER REPRODUCIBILITY.THE AIM OF THIS RESEARCH IS TO ISOLATE AND CHARACTERIZE ANTIGENS IN CIRCULATING IMMUNE COMPLEXES (CIC) FROM PATIENTS WITH ACQUIRED IMMUNODEFICIENCY SYNDROME AND KAPOSI'S SARCOMA (AIDS-KS) AND TO EXPLOIT THESE ANTIGENS FOR DEVELOPMENT OF NEW DIAGNOSTIC AND PROGNOSTIC REAGENTS. ELUATES FROM COLUMNS OF STAPHYLOCOCCUS AUREUSCOWAN I PROTEIN ...

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