Award Data

WE WILL DEVELOP A LASER SYSTEM THAT IS SUITABLE FOR PERFORMING PHOTOTHERMAL INTRASTROMAL KERATOPLASTY TO CORRECT OCULAR REFRACTIVE ERRORS. LASER PARAMETERS (WAVELENGTH, IRRADIANCE, AND IRRADIATION TIME) AND DELIVERY/GEOMETRY PARAMETERS (BEAM PROFILE, SPOT SIZE, PATTERN, AND SLEW RATE) SHALL BE OPTIMIZED FOR TREATMENT OF MYOPIA, HYPEROPIA, AND ASTIGMATISM. IN THE PHASE I PROGRAM RESEARCH, A PROTOTY ...

CYTOTOXIC ACTIVATED MACROPHAGES SECRETE SOLUBLE FACTORS THAT HAVE A VARIETY OF EFFECTS ON TUMOR CELLS. INCLUDED IN THE TUMOR CELL RESPONSE ARE THE INHIBITION OF MITOCHONDRIAL RESPIRATION AND INHIBITION OF DNA SYNTHESIS. A MONOKINE CALLED RIF, WHICH WAS FOUND TO REPRODUCE THESE EFFECTS IN VITRO, HAS BEEN CHARACTERIZED. THE ISOLATION AND VERIFICATION OF THE CDNA FOR RIF IS THE PRIMARY FOCUS OF THIS ...

N/A

ALZHEIMER'S DISEASE (AD), A LEADING HEALTH PROBLEM FOR THIS COUNTRY, AFFECTS 5 TO L0 PERCENT OF THOSE OVER 65. BY THE YEAR 2000, THIS AGING POPULATION WILL DOUBLE. A TEST PERMITTING A DEFINITIVE AND EARLY DIAGNOSIS OF AD IS GREATLY NEEDED. WE SEEK TO DEVELOP SUCH A DIAGNOSTIC TEST USING MABS IT HAS RAISED TO A MODIFIED FORM OF ALX. IN PHASE I STUDY, ART WILL CHARACTERIZE ITS MABS, DESIGN A PILOT I ...

THIS PROJECT WILL DEVELOP A SPECTROPHOTOMETRIC INSTRUMENT TO MEASURE THE TOTAL HEMOGLOBIN CONCENTRATION OF WHOLE BLOODAND THE RELATIVE CONCENTRATIONS OF OXY-, DEOXY-, CARBOXY-, MET-, AND SULFHEMOGLOBIN. THE CHIEF STRATEGY IS TO MAKE BEER'S LAW APPLY TO WHOLE BLOOD BY MINIMIZING THE EFFECTS OFLIGHT SCATTERING AND TO EMPLOY MATRIX MATH TECHNIQUES TO SOLVE FOR THE FIVE HEMOGLOBIN CONCENTRATIONS FROM ...

N/A

CURRENTLY, POULTRY PRODUCTS WHICH ARE PROCESSED AND DISTRIBUTED IN A NON-COOKED FORM, MAY CONTAIN SIGNIFICANT NUMBERS OF PATHOGENIC BACTERIA SUCH AS SALMONELLA, LISTERIA AND CAMPYLOBACTER. POULTRY PROCESSING TECHNOLOGY HAS NOT, AT THIS TIME, DEVELOPED A SYSTEM OF EVISCERATION THAT DOES NOT CONTAMINATE THE CARCASS TO SOME EXTENT. TECHNOLOGY TO ELIMINATE THESE CONTAMINATING PATHOGENS FROM THE CARCAS ...

RECENT RESEARCH HAS ESTABLISHED A NEW CLASS OF AUDITORY RESPONSES TERMED OTOACOUSTIC EMISSIONS THAT CAN BE OBJECTIVELY MEASURED IN THE EAR CANAL OF ALL NORMAL HEARING INDIVIDUALS. THUS, IT IS NOW POSSIBLE TO DEVELOP OBJECTIVE HEARING-SCREENING INSTRUMENTS FOR THE ASSESSMENT OF DYSFUNCTION BASED UPON THE ABSENCE OF EMITTED RESPONSES. ONE TYPE OF EMISSION ELICITED BY THE APPLICATION OF CONTINUOUS PU ...

THE PROJECT'S LONG-TERM OBJECTIVE IS TO DEVELOP AN ENHANCED,COMPUTERIZED HEALTH RISK APPRAISAL, THE ALL-CAUSE MORTALITY RISK PROFILE (ACMRP), INCORPORATING AN OBJECTIVE MEASURE OF PHYSICAL FITNESS, THE MAXIMAL GRADED TREADMILL STRESS TEST, INTO MORTALITY RISK FACTORS. MORE THAN 17,000 PATIENTS WITHOVER 140,000 PERSON-YEARS OF FOLLOWUP IN THE ONGOING AEROBICS CENTER LONGITUDINAL STUDY (ACLS) HAVE B ...

DURING THE LAST 20 YEARS, ALLOGRAFT HEART VALVE TRANSPLANTATION IN THE UNITED STATES HAS INCREASED FROM ABOUT 50 TO 2,000 PER ANNUM. BECAUSE OF THIS INCREASED DEMAND, PARTICULARLY FOR PEDIATRIC CASES, UTILIZATION OF THESE CRYOPRESERVED HEART VALVES IS NOW LIMITED BY THE SUPPLY OF DONATED HUMAN HEARTS. THE OBJECTIVE IS TO CONVERT XENOGRAFT HEART VALVES INTO ALLOGRAFTS IN AN ATTEMPT TO RESOLVE THIS ...