Award Data

Preventing Vascular Complications in Type 1 Diabetes: Muscle Metabolic Monitoring Abstract Measurements of muscle metabolism and blood flow using near infrared spectroscopy (NIRS) have progressively increased, as has the number of companies selling NIRS-based devices. This technology represents the present and future modality for non-invasively characterizing normal and abnormal muscle physiology ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase I project will result from a focus on families with low socioeconomic status (SES), in whom adverse childhood experiences (ACE) and opioid use disorder (OUD) are common. Children of parents with OUD have higher incidences of ACE due to neglect, physical abuse, or domestic violence. ACE have life-long ad ...

The broader impact/commercial potential of this Small Business Innovation Research (SBIR) Phase II project is to reduce injuries and costs due to overexertion and heat strain in firefighting through a real-time, biometric monitoring system and accompanying analysis tools. This system collects each firefighter's vital signs and sends the data to authorized commanders for real-time strategic decisio ...

The high spatial resolution and energy resolution of cadmium zinc tellurideCZTand cadmium tellurideCdTecompared to that of scintillatorsoffers superior image quality in Nuclear medicine and X rayimaging applicationsi eSPECTPETCTBone DensitometryOncologyDental imagingAirportsecurityetcEven after two decades of researchCZT and CdTe remain the desired choice for roomtemperature radiation detectionbut ...

PROJECT SUMMARY ABSTRACTAtrial fibrillationAFis a common and chronic cardiac arrhythmia that significantly increases morbiditymortalityand healthcare costsPost operative AF after cardiac surgery is especially commonIt complicates recovery in up toof patients undergoing coronary artery bypass surgeryIn the United States postoperative AF prolongs hospital stayincreases costand increases short and lo ...

PROJECT SUMMARY ABSTRACT The development of a low costpoint of care diagnostic device or kit in arapid testorself testformat would be highly beneficial to the global effort to diagnosemanage and treat HIVWe are proposing to evaluate the scientific finding that HIV proteins are present in urine associated with extracellular vesiclesalso commonly referred to as exosomesThe development of one or more ...

Project Summary The goal of this project is to develop a multimodal neuromodulatory opioid sparing device for low back paindemonstrate effective pain reliefthen evaluate opioid reduction for patients with acute or chronic back pain presenting for treatmentPain and opioid use disorderOUDare intricately relateddependence begins for up towith medications prescribed for paineither directly or through ...

Chronic myeloid leukemiaCMLis caused by a translocation between chromosomesandwhere the BCR gene promoter drives overexpression of ABL kinaseThis rearrangement causes transformation of bloodforming cells of the bone marrow and accounts forof all new leukemia cases in adultsThree generations of tyrosine kinase inhibitorsTKIshave been developed that are used clinically to inhibit the ABL kinase in C ...

The broader impact of this SBIR Phase II project will be achieved through further development of a novel physical music media platform with advanced instrumentation that is designed to promote deeper engagement in education for underrepresented youths. The platform will provide much needed educational support for youths' STEAM (science, technology, engineering, arts, and math) learning. The techno ...

Parkinsonandapos;s Disease (PD) is a progressive neurodegenerative disorder that affects ≈1 million patient in the U.S. annually and 7 to 10 million people worldwide. PD is characterized by disorders of movement, which are caused by the progressive loss of dopamine neurons in the substantia nigra pars compacta (SNpc), and autonomic dysfunction, anxiety, depression, sleep disorders and cognitive ...