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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Development of a transgenic mouse line engineered to permit selection and cloning

    SBC: ABEOME CORPORATION            Topic: NCRR

    DESCRIPTION (provided by applicant): The Applicant proposes an improvement to monoclonal antibody technology through the generation of transgenic mice engineered to facilitate flow cytometric isolation and cloning of specific antigen-reactive plasmacytes. Monoclonal antibodies (mAbs) are arguably the most important biological reagents used in biomedical research, diagnostics, and therapeutics, and ...

    SBIR Phase I 2010 Department of Health and Human Services
  2. Simultaneous Stimulation and Recording in Scalable Microelectrode Arrays

    SBC: Axion Biosystems, Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): The proposed study utilizes novel electronics and microfabrication techniques to create scalable, in-vitro Microelectrode Array (MEA) technologies that conform to industry standards for multiwell plates. This research will not only enable rapid advancements in the study of network-level electrophysiology, but it will also create new opportunities for pharmaceut ...

    SBIR Phase II 2010 Department of Health and Human Services
  3. Multi-Line Refreshable Braille Display

    SBC: TACTILE DISPLAY CORPORATION            Topic: NEI

    DESCRIPTION (provided by applicant): The project proposed by Tactile Display Corporation (TDC) supports the NIH/NEI mission to develop devices to aid the blind. A blind student has 2 hurdles to overcome when reading with today's refreshable braille display (RBD): the inability to read more than one line at a time because these devices only display a single line of text, and, the inability to read ...

    SBIR Phase II 2010 Department of Health and Human Services
  4. Paragraph and Essay Writing Instruction for Struggling Secondary Writers

    SBC: EDGE ENTERPRISES, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): The purpose of this fast-track SBIR project entitled Paragraph and Essay Writing Instruction for Struggling Secondary Writers is to develop and evaluate the effectiveness of a total of four interactive multimedia (IM) software programs to be used to teach complex writing skills to struggling writers in secondary schools. The foci of the four programs will be ...

    SBIR Phase II 2010 Department of Health and Human Services
  5. DNA Detection Switch (DDS) probes for diagnosis of multi-drug resistant tuberculo

    SBC: GENETAG TECHNOLOGY, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): DDS diagnostic probe systems for MDR-TB Principal Investigator, Shafer, David A. PhD Abstract: Tuberculosis (TB) is a primary cause of morbidity and mortality in many areas of the world with about 8 million new cases and 2 million deaths per year. In recent years, there has been a rapid and alarming increase in the incidence and spread of drug resistant TB and ...

    SBIR Phase I 2010 Department of Health and Human Services
  6. Multichannel Electrosonic Actuation Microarray for Cell-Based Screening

    SBC: OPENCELL TECHNOLOGIES, INC.            Topic: NCRR

    DESCRIPTION (provided by applicant): High-throughput, parallel delivery and transfection of biologically relevant material into cells remains a difficult task. The proposed work addresses this issue through integration of multiple Electrosonic Actuation Microarrays (EAMs) into a single MIST (Multiple Integrated Sample Treatment) device that is optimized for parallel drug and/or gene/nucleic acid d ...

    SBIR Phase I 2010 Department of Health and Human Services
  7. Attitude Boost: A multimedia curriculum to improve attitudes toward science

    SBC: KDH Research And Communication, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): The purpose of this Fast Track SBIR is to develop and evaluate a series of curriculum supplements, entitled Attitude Boost, which aims to improve students' positive attitudes toward science, with the goal, in turn, of improving scientific literacy and academic performance on science subjects, particularly those related to drug abuse education and prevention. At ...

    SBIR Phase II 2010 Department of Health and Human Services
  8. POP-D: A science-education program for teens on prescription and over-the-counter

    SBC: KDH Research And Communication, Inc.            Topic: NIDA

    DESCRIPTION (provided by applicant): In this Fast Track application, KDH Research and Communication, Inc. (KDHRC) will develop a school-based, science education curriculum specifically on prescription and over-the-counter (Rx/OTC) drugs, tentatively entitled POP-D (Proper use of Over-the-counter and Prescription Drugs). Because Rx/OTC abuse has many distinctions from illegal drugs, including commo ...

    SBIR Phase II 2010 Department of Health and Human Services
  9. PREVENTING PRESCRIPTION DRUG DIVERSION IN SCHOOLS

    SBC: KDH Research And Communication, Inc.            Topic: NIDA

    In this Phase I SBIR project, KDHRC will create and evaluate SecuRx.com, a website to prevent prescription drug abuse in schools.

    SBIR Phase I 2010 Department of Health and Human Services
  10. Motor neuron disease modeling in Zebrafish

    SBC: Luminomics Inc.            Topic: NINDS

    DESCRIPTION (provided by applicant): 1 Our ultimate goal is to discover how cells targeted for destruction during degenerative disease 2 can be regenerated from adult stem cells. The specific goal of this proposal is to create 3 transgenic zebrafish that can be used to model the regeneration of motor neuron (MN) cells, the 4 cell type lost in all motor neuron diseases (MND). Zebrafish have a r ...

    SBIR Phase I 2010 Department of Health and Human Services

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