Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Development of Site-specific O-GlcNAc Antibodies for Epigenetic Research

    SBC: GlycoScientific, L.L.C.            Topic: 300

    Project SummaryO glycosylation of nuclear and cytoplasmic proteins by a singleN acetyl D glucosamine moietyOGlcNAcis a common post translational modification that is highly dynamic and fluctuates in response to cellular stimuliThis type of glycosylation has been found on approximately a thousand human proteins to dateand is thought to be nearly as wide spread and abundant as protein phosphorylatio ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  2. Reagents specific for all N-glycans

    SBC: GLYCOSENSORS AND DIAGNOSTICS, LLC            Topic: 400

    PROJECT SUMMARY Glycans have several distinct properties that make them excellent targets for disease biomarkersFirstlytheir location glycans on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesSecondlycell surface molecules are also strategically exposed for surveillance by the immune system allowing ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Engineering probiotics to biosynthesize natural substances for microbiome brain research

    SBC: HGG Research LLC            Topic: R

    PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Noninvasive Contrast Enhanced Early Detection of Melanoma Liver Metastasis

    SBC: INLIGHTA BIOSCIENCES L.L.C.            Topic: 102

    Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

    STTR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Tough Talks: A Disclosure Intervention for HIV+ YMSM

    SBC: VIRTUALLY BETTER INC            Topic: 105

    PROJECT SUMMARY Men who have sex with menMSMaccount for nearly two thirds all of new HIV infections in the United StatesUSand young MSMYMSMare the only risk group experiencing a significant increase in HIV incidenceAmong youthpercent report not disclosing to their first time sex partnersDisclosing of one s HIV status is important for accessing support which can lead to improved medication adherenc ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Preventing Vascular Complications in Type Diabetes Muscle Metabolic Monitoring

    SBC: Infrared Rx, Inc.            Topic: NIDDK

    Project Summary Abstract While much has been accomplished in managing hyperglycemia morbidity and mortality in patients with type diabetes T D often results from cardiovascular complications Evidence suggests peripheral artery disease and skeletal muscle mitochondrial dysfunction One reason is the lack of reliable tools to characterize skeletal muscle microcirculation and mitochondrial capa ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. IND enabling studies for a personalized immunotherapy for triple negative breast cancer

    SBC: METACLIPSE THERAPEUTICS CORPORATION            Topic: NCI

    Abstract The worldwide incidence of breast cancer ismillionTriple negative breast cancersTNBCaccount forof total breast cancer casesworldwideAnnuallyovernew cases of TNBC are diagnosed in the US aloneThe treatment options for TNBC patients are limitedTriple negative breast cancerTNBCincludes breast cancers that lack estrogen receptorprogesterone receptorand HERproteinsLack of known targets and pat ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Aerosolized platinum nanoparticle chemotherapy for lung cancer

    SBC: HYLAPHARM LLC            Topic: 102

    Significance Lung cancer is the leading cause of cancer deaths with over new diagnoses annually Survival rate of lung cancer patients is correlated with the extent of lymph node metastasis Standard care includes chemotherapy radiation and or surgery Cisplatin is a first line chemotherapy for lung cancer but systemic intravenous IV delivery is confounded by various toxicities rena ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. Small molecule therapy for metastatic prostate cancer

    SBC: MetCure Therapeutics LLC            Topic: 102

    Enzalutamide resistance is a major obstacle in the treatment of metastatic castration resistant prostate cancer mCRPC Recently we developed a small molecule lead compound GH and demonstrated its potent activity against bone metastatic prostate cancer cells In this Phase I STTR application we hypothesize that GH is a novel lead compound with nanomolar potency against enzalutamide resist ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. Phase 1 Clinical Evaluation of NP10679, a GluN2B Selective,Context-Dependent NMDA Receptor Inhibitor for Subarachnoid Hemorrhage

    SBC: NEUROP, INC.            Topic: 102

    Abstract Subarachnoid hemorrhageSAHremains a serious source of neurological morbiditywith approximatelycases reported in the US each yearDespite advances in treating the initial and subsequent bleedspost surgical clipping of the aneurysm is associated with a significant risk of delayed cerebral ischemiaDCIThese events typically occur within the firstdays after aneurysmal rupture and DCI remains th ...

    SBIR Phase II 2017 Department of Health and Human ServicesNational Institutes of Health
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