Award Data

Project SummaryO glycosylation of nuclear and cytoplasmic proteins by a singleN acetyl D glucosamine moietyOGlcNAcis a common post translational modification that is highly dynamic and fluctuates in response to cellular stimuliThis type of glycosylation has been found on approximately a thousand human proteins to dateand is thought to be nearly as wide spread and abundant as protein phosphorylatio ...

PROJECT SUMMARY Heart attackor acute myocardial infarctionAMIis a leading cause of death in the United Stateswith overvictims every yearThe most prevalent cause of AMI is progressive thrombotic coronary artery occlusionalso known as ST segment elevation myocardial infarctionSTEMIEarly therapy to promote heart reperfusion can dramatically improve outcomesWhile percutaneous coronary interventionPCIi ...

Chikungunya virusCHIKVis an alphavirus that has gained significant attention due to its ability to cause large epidemics among susceptible populations and to be spread beyond endemic countries by international travelersAmong a population of approximatelyon the French island of La Reunionpeople were infected and overCHIKV related fatalities occurred during theoutbreakLikewisean estimatedmillion peo ...

PROJECT SUMMARY Glycans have several distinct properties that make them excellent targets for disease biomarkersFirstlytheir location glycans on cell surfaces makes them the first point of contact for cellular interactionsand thus they are crucial in the control of normal metabolic processesSecondlycell surface molecules are also strategically exposed for surveillance by the immune system allowing ...

Abstract The liver is the most common organ for metastasis of various cancersincluding pancreaticovariancolorectalgastric cancers and melanomaUveal melanoma metastasizes inof patients and upon metastasis targets the liver inof these casesThe most common primary malignant liver cancer worldwide is hepatocellular carcinomaHCCThe use of blind liver biopsy as a diagnostic tool for liver cancer has man ...

PROJECT SUMMARY To advance microbiome brain studies the general goals of this collaborative proposal are to provide services to research community by engineering probiotics e g E coli Nissle EcN Bifidobacteria longum Lactobacillus plantarum to biosynthesize various naturally occurring chemicals as prebiotic probiotic conjugates which will be marketed as important laboratory agents ...

PROJECT SUMMARY Men who have sex with menMSMaccount for nearly two thirds all of new HIV infections in the United StatesUSand young MSMYMSMare the only risk group experiencing a significant increase in HIV incidenceAmong youthpercent report not disclosing to their first time sex partnersDisclosing of one s HIV status is important for accessing support which can lead to improved medication adherenc ...

Project SummaryWhile the mosquito borne illness malariais entirely preventable and treatablecountries are currently plagued by malaria transmission and half the world s population is at risk of malariaA great deal of progress has been made against malaria as a result of the massive rollout of resources and technology focused on malaria controlThirty five of theaffected countriesincluding China and ...

Inhibikase Therapeutics is a clinical stagebiopharmaceutical company that has developed a hosttargeted mechanism of action to treat AIDS related and drug induced progressive multifocal leukoencephalopathyPMLPML is a demyelinating disease of the central nervous system and was rarely seen clinically until the era of the HIV epidemic began in the midsDuring the height of the epidemicthe rate of PML o ...

Project Summary Frailty is a common clinical condition in which older adults are at high risk for fallsdisabilityhospitalizationand deathApproximatelyof adultsyears or older are frail andare prefrail with high risk of progressing to frailtyCurrent screening for frailty hinges on infrequent o ce visits and a patient s report of symptomswhich often fail to detect subtle declineImpaired physical func ...