Award Data

RoadNarrows proposes a novel architecture to be implemented in a 6DOF vision system with applications in autonomous robotics. The system will report objects of interest along with location and pose information to a supervising computer. This system will be built around an advanced 3D vision platform that can deliver multiple video streams and 3D spatial measurements. The sensors will deliver high- ...

The SBIR solicitation expressed the need for tools to process data from disparate sources in various formats and generate drought-relevant data products. NIDIS also recognizes a need to span organizational boundaries to provide access to integrated drought information for use in water management. The Phase I SBIR project resulted in prototype Climate Information Management Toolkit (CIMT) software ...

An operational optical particle counter will be built, extensively characterized and evaluated that measures the size and shape of aerosol particles with optical diameter from 0.1 to 10 μm. This instrument will distinguish different species of dust and volcanic ash from other types of aerosol particles, and provide an estimate of the aerosol optical properties and produce compositional informati ...

DESCRIPTION (provided by applicant): We have discovered, characterized and functionally defined a novel, immune inhibitory ligand. This ligand is hematopoietically-expressed, a distant member of the B7 Ig-superfamily, and its extracellular domain bears homology to the B7 family ligand PD-L1. This molecule is designated as V-domain Immunoglobulin Suppressor of T cell Activation (VISTA). Distinct fr ...

DESCRIPTION (provided by applicant): Systemic sclerosis (SSc) is an autoimmune disease that presents with a heterogeneous and complex phenotype. Major manifestations of the disease are skin fibrosis, vascular dysfunction, and immune system activation. There are no validated diagnostic markers. There are no curative treatments. One in three patients dies within 10 years of diagnosis. Some drugs (de ...

DESCRIPTION (provided by applicant): Nearly half of all college students have a diagnosable mental health problem (Blanco et al., 2008). College counseling centers (CCCs) are faced with increasing demands for services from Universities, students and parents to meet the treatment needs of their students (Beamish, 2005), in the context of increasingly severe cases and declining resources (Gallagher, ...

DESCRIPTION (provided by applicant): The objective of this Phase 1 project is to improve an effective treatment of recurrent small-cell lung cancer (rSCLC) by targeting a tumor-specific abnormal receptor, AbnV2 that is a surface-marker of the disease. Currently, there is no effective treatment for rSCLC. Our data show expression of this abnormal vasopressin V2 receptor (AbnV2 ) is a common featur ...

DESCRIPTION (provided by applicant): Where arm functioning has been compromised due to a stroke, brain injury, or other neurological injury and rehabilitative progress is to be obtained in the upper extremity, it is crucial to limit over-stretching of theshoulder joint (attributed to lost muscle tone) and to control pain. Medeon, LLC is actively working with rehabilitation experts to develop the ...

DESCRIPTION (provided by applicant): Among amputation types involving the upper limbs, partial hand is the most prevalent by far and among the most challenging for prosthetists to address well. Sound side overreliance for these amputees gives rise to a high prevalence of contralateral overuse syndrome (COS), a progressive, painful, and debilitating condition. Research shows that prostheses reduce ...

DESCRIPTION (provided by applicant): Introduction of small interfering RNAs (siRNAs) into cells with transfection reagents results in efficient gene silencing. Unfortunately, while siRNA-based functional genomics is widely used in vitro, the ability to apply this technology to primary cells and in vivo target validation has been impeded limited availability of efficient and non-toxic delivery syst ...