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Optofluidics will develop Protein Qspec, a new particle analysis QC instrument designed to characterize protein aggregates in biologic drugs. The primary concern for this class of therapeutics is that they can elicit an immune response from patients who develop anti-drug antibodies which can eliminate the therapeutic benefit. The presence of particulate matter, in these therapeutics (e.g. shed gla ...

A spray vacuum freezing desalination process is proposed to meet the required seawater desalination cost, with water subcooling suppression at freezing. The cost of the proposed desalination method is low, with low energy requirement and minimum carbon emission. General statement of how this problem is being addressed: Nucleating agents will be used to suppress subcooling of freezing the sprayed s ...

An increasingly developed global population necessitates an increased demand for inexpensive energy, which must be clean, efficient, and renewable in order to prevent adverse effects on future resources and the climate. Biodiesel has emerged as a renewably-produced, potentially carbon-neutral hydrocarbon, making it an attractive alternative to conventionally-obtained fossil fuels. Nevertheless, st ...

The development of a permanent national repository for storing the spent nuclear fuel generated by our nuclear power plants has taken longer than initially predicted by the US DoE. As a result, the licensees have been required to keep their spent fuel in the spent fuel pools or in an Independent Spent Fuel Storage Installation (ISFSI). The ISFSI contents are externally monitored for changes, but t ...

The SCO2 Brayton cycle is gaining interest across a variety of power generation applications due to its potential for providing higher efficiencies. The range of industrial applications include: industrial waste and heat recovery, coal and nuclear power plants, and renewable energy sources such as solar thermal and fuel cells. All of these cycle loops require compressors that operate near the crit ...

FPoliSolutions, LLC (FPS) proposes to develop and commercialize an integrated data and simulation management framework. FPS would build from the current RAVEN technology developed by INL for the purposes of commercializing an integrated data and simulation management framework for design optimization studies. RAVEN is essentially a workflow engine with the capability to drive simulators and model ...

The Smart Grid is essential to meeting our future energy needs by changing how we use, distribute, and generate electricity. This energy future includes an increased amount of energy from renewable resources, load management techniques to improve resiliency and reliability, and distributed energy resources that can be managed to meet energy provider and individual customer’s needs. Two primary S ...

Low-cost, power-efficient, time-resolved imaging is increasingly important for DOE remote sensing operations. While large-area CMOS and CCD visible imagers and high-resolution thermal imagers now provide excellent images, these technologies do not have the temporal resolution to detect and track transient events, such as lasers, muzzle flashes, or other energetic events. Needed are imagers that ha ...

With 27% of the world’s coal reserves located in the United States, development of a clean, efficient, and economically viable pathway to coal utilization is of strategic importance. Development of advanced coal-to-liquids technologies provides this direct pathway, while improving energy security, reducing coal environmental footprint, and promoting economic development directly in the communiti ...

Detectors and radiation monitors for future high energy and nuclear physics experiments must be able to withstand radiation environments several orders of magnitude harsher than those of any current device. At present, most radiation detectors are based on silicon technology, however, the practical radiation tolerance of silicon falls far short of requirements in future experiments and silicon mus ...