Award Data

Optofluidics will develop Protein Qspec, a new particle analysis QC instrument designed to characterize protein aggregates in biologic drugs. The primary concern for this class of therapeutics is that they can elicit an immune response from patients who develop anti-drug antibodies which can eliminate the therapeutic benefit. The presence of particulate matter, in these therapeutics (e.g. shed gla ...

DESCRIPTION provided by applicant Modern radiation therapy treatment modalities such as intensity modulated radiation therapy are associated with complex dose distributions and sharp dose gradients Experimental dose validation using multidimensional high spatial resolution dosimeters is mandatory The product to be developed is a novel high resolution dosimetry system that combines reusabil ...

DESCRIPTION provided by applicant In nearly million new cancer cases are estimated to occur in the US where nearly two thirds will have treatment by radiation therapy In current clinical practice organ contour delineation on medical images is still performed with low levels of automation due to lack of highly automated commercial contouring software This deteriorates therapy plann ...

DESCRIPTION provided by applicant The proposed research is the study of new paradigms in both the treatment of cancer and cancer drug development This platform technology will markedly expand the number of cancer specific surface receptors and antigens that can be targeted for drug delivery using peptide ligands The general principle of this new technology is that cancer cells respond to ioni ...

DESCRIPTION provided by applicant Metastatic clear cell renal cell carcinoma mccRCC is an incurable cancer with a year survival of less than for which novel therapeutic agents need to be developed urgently It is notoriously resistant to chemotherapy and radiation Although molecularly targeted therapies have led to an improvement in survival the benefit is rather limited due to event ...

DESCRIPTION provided by applicant This proposed project will further develop a CFC off loading AFO designed to offload plantar pressures and optimize patient function through maximizing plantarflexor power production During Phase I we will determine the effects of varying design characteristics of CFC off loading AFOs We will refine and create new FEA models and algorithms that predict the ...

DESCRIPTION In communities across the United States clinical populations exhibiting mental health and or substance abuse disorders face substantial challenges in accessing and receiving high quality and effective behavioral healthcare services Health Information technology HIT has been identified as an important component of improving access to behavioral healthcare in rural communities yet t ...

DESCRIPTION provided by applicant Trichomonas vaginalis is the causative agent of the most common non viral sexually transmitted infection with million new cases reported annually in the world and million cases in the U S In addition to infections of the urogenital tract trichomoniasis increases the risk of adverse pregnancy outcomes and HIV transmission and increases the incidence ...

DESCRIPTION provided by applicant Noise is the most common occupational and environmental hazard thus it is not surprising that noise induced hearing loss NIHL is the second most common form of sensorineural hearing deficit second only to age related hearing loss Although therapeutics that target the free radical pathway have shown promise for reducing NIHL there are no medications approv ...

DESCRIPTION provided by applicant Cognition Therapeutics Inc andapos s mission is to develop effective therapeutics for Alzheimerandapos s disease Recent scientific discoveries have identified oligomers of the brain protein Abeta as toxic culprits in the disease process Cognition has discovered therapeutic molecules that displace Abeta oligomers from neurons and block the downstream pathol ...