Award Data

Optofluidics will develop Protein Qspec, a new particle analysis QC instrument designed to characterize protein aggregates in biologic drugs. The primary concern for this class of therapeutics is that they can elicit an immune response from patients who develop anti-drug antibodies which can eliminate the therapeutic benefit. The presence of particulate matter, in these therapeutics (e.g. shed gla ...

A robust system level design process will be used to identify the design of transparent tapered resistive (TTR) elements, including the materials, fabrication processes, and lifecycle costs. The transparent tapered resistive film will be designed to provides a tapered resistive layer across the film while remaining transparent in the visual and near-infrared optical bands for use in radio-frequenc ...

Vibrant Corporation and Sandia National Laboratories (SNL) propose to apply Process Compensated Resonance Testing (PCRT) to the DLA's need for an NDI method to detect counterfeit, nonconforming and improperly processed materiel. PCRT collects and analyzes the resonance frequencies of a component to detect structural defects, characterize material, analyze population variation, monitor manufacturin ...

X-ray fluorescence spectroscopy is a widely used and extremely sensitive analytical technique for qualitative and quantitative chemical analysis. Superconducting Transition Edge Sensor (TES) microcalorimeter detectors have now been developed that achieve an energy resolution of 2 eV for 1.5 keV X-rays, which is sufficient to enable the measurement of the small shift of the X-ray line position that ...

Since 1990, Prime Synthesis, Inc. (PSI) has been a leading manufacturer of controlled pore glass (CPG). It has developed significant expertise in the optimization of physical characteristics and chemical modifications of CPG for a variety of applications. CPG has a unique combination of attributes including a very uniform, three-dimensional, nanopore structure that is dimensionally stable in organ ...

In the proposed effort, we will leverage this extensive experience and capabilities to realize a frequency agile mmW radiometer that can cover the range of DC-110 GHz and can be scaled to DC-200 GHz under Phase II. Ours is a photonic system that multiplies and up-coverts a low-frequency reference signal onto an optical carrier (laser) using EO modulation, then uses the modulation sidebands to inj ...

In an effort to support the development of a domestic marine aquaculture industry, Zeigler Bros. Inc., (ZBI) proposes to continue its Phase I research by demonstrating the ability to scale up inclusion particle (IP) manufacturing. During Phase II ZBI will also demonstrate the efficacy of IOs for orally delivering phytase and probiotics to marine finfish. These efforts will directly address the p ...