Award Data

Abstract Cell based assays more closely mimic biology than direct inhibition studies Therefore drug discovery companies are increasingly utilizing cellular screening assays Current reporter systems are unable to reliably measure in cell transient protein protein interactions Furthermore many are based upon split enzyme systems which require long incubation steps are not real time and are ty ...

Project Summary Mobility limitations including gait and balance impairments are common in older adults and are a major cause of falls and reduced quality of life Although laboratory studies show that biofeedback during exercise training can improve motor performance physical therapists do not have access to an overground gait biofeedback system for their patients We will develop Mobility Rehab ...

This Phase II project will develop a computer based tool for the functional assessment of higher level instrumental activities of daily living IADLs using simulated activities in a virtual environment VE IADLs are the high level activities such as managing finances and complex medication regimens and successfully negotiating novel or new situations that are necessary for fully independent liv ...

Abstract Project Summary Cognition Therapeutics Inc CogRx has discovered CT a novel oligomer receptor antagonist that is the only drug candidate demonstrated to prevent and displace binding of Abeta oligomers to receptors on brain cells By stopping the initiating event in the Abeta oligomer cascade this first in class drug candidate completely blocks downstream synaptotoxicity and rest ...

Project Summary Falls are the leading cause of injurieshospital visitsnursing home admissionsand reduced quality of life for people with neurological disordersAlthough there is consensus that impaired mobility is the basis for most fallsit is very di cult to evaluate these complex abilities outside a laboratory settingBrief clinical examinations do not accurately re ect dailyfunctional mobility in ...

Summary VisionQuest Biomedical LLCVisionQuesthas developed a diabetic retinopathyDRscreening systemEyeStarenabled by automated screening softwareDR RACSthat was developed under the EYPhase II SBIR projectOur product provides immediate feedback to the physician on the state of diabetic eye disease without burdening an eye care specialist to review those cases without retinal diseaseDiabetes affects ...

Abstract Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of significant unmet medical need ...

Summary VisionQuest Biomedical LLC VisionQuest has developed a diabetic retinopathy DR screening system EyeStar enabled by automated screening software DR RACS that was developed under the EY Phase II SBIR project Our product provides immediate feedback to the physician on the state of diabetic eye disease without burdening an eye care specialist to review those cases without retin ...

The objective of this research project is to update a web application Overcoming Addictions OA and enable it to be efficiently used by treatment providers in addition to its current use by the general public OA is an abstinence focused cognitive behavioral intervention based on the four point program for SMART Recovery www smartrecovery org We have already demonstrated the effectiveness of ...

The objective of this research project is to update a web application Overcoming Addictions OA and enable it to be efficiently used by treatment providers in addition to its current use by the general public OA is an abstinence focused cognitive behavioral intervention based on the four point program for SMART Recovery www smartrecovery org We have already demonstrated the effectiveness of ...