Award Data

This Small Business Innovation Research (SBIR) Phase I project will develop a surface coating technology that will be used to create improved materials for regulating cell behavior for research, tissue engineering and cell therapy applications. For these applications, advanced materials are needed that display multiple types of active proteins, while preventing nonspecific protein adsorption. Curr ...

This Small Business Innovation Research Phase I research project aims to establish "proof-of-concept" of a novel Software Platform directed at needs of FDA's Process Analytical Technologies (PAT) initiative, a framework for innovative pharmaceutical development, manufacturing and quality assurance. PAT is implemented at three levels: Process Understanding; Quality by Design; and Monitor, Predict a ...

There is an acute need for a networked chemical sensor that is inexpensive enough to allow it to be treated as a disposable item - deployed and left in-place until the end of its useful life, or until operations move out of communications range. Electrochemical microarray sensors can be fabricated at low enough unit cost to make the development of a disposable sensor node feasible. These sensors ...

This Small Business Innovation Research (SBIR) Phase I study is aimed toward development of an efficient procedure for predicting growth of ternary III-V semiconductor materials grown by Metal Organic Vapor Phase Epitaxy (MOVPE). These techniques are now used extensively in the semiconductor industry to model growth of materials on substrates by chemical vapor deposition. The success of such model ...

This Small Business Innovation Research (SBIR) Phase II project will develop and customize advanced simulation software for the design and optimization of microsphere and cell-based assays. Current assay design by trial and error is slow, unreliable, expensive, and a bottleneck for multiplexed, high-throughput analysis. Prior Phase I research has successfully established a first-ever, truly int ...

This Small Business Innovation Research (SBIR) Phase II project will develop and customize advanced simulation software for the design and optimization of microsphere and cell-based assays. Current assay design by trial and error is slow, unreliable, expensive, and a bottleneck for multiplexed, high-throughput analysis. Prior Phase I research has successfully established a first-ever, truly int ...

This Small Business Innovation Research (SBIR) Phase I project will develop a new process of low-temperature synthesis of aligned carbon nanotubes (CNTs) and nanofibers (CNFs). CNTs/CNFs are widely studied for manufacturing of novel nanomaterials and nanodevices. The prospects of this manufacturing are currently limited by the high (above 500 deg C) surface temperature during CNT/CNF synthesis, ...

Our solution to the automated feature extraction problem will leverage the material properties that can be inferred from combining multispectral imagery with high resolution elevation data or LIDAR data using a trainable knowledge base. Multiple imaging bands provide a more complete picture of the material involved than ordinary RGB. This can help distinguish between a green grass lawn and a gre ...

This Small Business Innovation Research (SBIR)Phase I research project will investigate technology innovations needed to support the automated analysis and improvement of the reusability characteristics of digital learning resources. Reusability of digital learning resources is crucial to increasing access and lowering the cost of online training and education. Recent advances in the theory of reu ...

This Small Business Innovation Research Phase I project is aimed at optimizing the mass-transport properties of the cathode electrode for high temperature (120C), and dry air operation. The overall objective is to fabricate complete catalyst coated membranes utilizing the newly engineered cathode electrode layer, and test the improvements in a high temperature(120C) fuel cell. A second objective i ...