Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until September, 2020.

  1. Screening of glucocorticoid receptor small-molecule regulators using cognate site

    SBC: VISTAMOTIF LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. EMG biofeedback with AMES

    SBC: AMES TECHNOLOGY, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): The long-range goal of this project is to restore functional movement to low-functioning stroke patients using a novel therapeutic regimen and robotic device called AMES, an acronym for Assisted Movement with Enhanced Sensation. In AMES-as it is currently used-the patient's affected limb is moved cyclically with the AMES robotic device while the sensation of ...

    SBIR Phase II 2009 Department of Health and Human Services
  3. A Photoelectrocatalytic Device for Removing MTBE from Water

    SBC: AQUAMOST, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

    SBIR Phase I 2009 Department of Health and Human Services
  4. Pharmacological Impact of 3-Dimensional Extracellular Matrix on Tumor Cells

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There is a strong need in drug discovery for cellular assays that better predict human responses to drugs. A key technical hurdle has been the difficulty of incorporating 3-dimensional extracellular matrix into a powerful assay format that is compatible with the high throughput approaches used for early drug discovery. In this proposal we intend to develop the ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. Enhanced ADP Immunoassay for Multimode Kinase Detection

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Kinases are the most intensively screened class of enzymes being targeted for therapeutic intervention because of their central role in regulating the function of other biomolecules. Strategies for developing selective kinase inhibitors are evolving rapidly, creating a demand for more flexible methods for measuring kinase activity in high throughput screening c ...

    SBIR Phase I 2009 Department of Health and Human Services
  6. HTS Assays for Modulators of GPCR Signaling

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-psychotics, as well drugs used for neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The relatively recent discovery of a ...

    SBIR Phase II 2009 Department of Health and Human Services
  7. A microfluidic chemotaxis device for high content screening

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as atherosclerosis. Whereas current anti-inflammatory drugs such as NSAIDs target secondary effects that are induced after inflammation is already est ...

    SBIR Phase II 2009 Department of Health and Human Services
  8. Computer assisted disfluency counts for stuttered speech

    SBC: BIOSPEECH INC            Topic: N/A

    DESCRIPTION (provided by applicant): Stuttering is a communication disorder characterized by disfluencies that are frequent and disruptive to communication. Clinicians extensively use disfluency counts to decide whether a client should be treated, to assess treatment progress, and to document treatment outcomes. Clinicians often do disfluency counts in real-time as a speaker is talking. However, ...

    STTR Phase I 2009 Department of Health and Human Services
  9. Tools for Automated Assessment of Language

    SBC: BIOSPEECH INC            Topic: N/A

    DESCRIPTION (provided by applicant): Language and communication problems critically characterize a number of neurodevelopmental disorders including Developmental Language Disorders (DLD) and Autism Spectrum Disorders (ASD). It is increasingly recognized that assessment should include spontaneous natural language samples. There are measures, such as the Index of Productive Syntax (IPSyn), which are ...

    STTR Phase I 2009 Department of Health and Human Services
  10. Evaluating BMY-14802 as an anti-dyskinesia treatment in the 6-OHDA rat model of P

    SBC: SKYBRIDGE PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Our objective is to develop new drug treatments for the side effects of levodopa (L-DOPA) that occur in people with Parkinson's Disease. L-DOPA is the gold standard of treatment for Parkinson's, but unfortunately, the majority of people who take L-DOPA eventually develop debilitating side effects, abnormal involuntary movements called dyskinesias, which may aff ...

    SBIR Phase I 2009 Department of Health and Human Services
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