Award Data

This Small Business Innovation Research Phase II project will develop targeted nanoparticle delivery systems capable of delivering conventional cytotoxics preferentially to tumor cells. While therapeutic nanoparticles have been introduced into clinical practice (Abraxane(TM) and Doxil(TM)) and others are in development, none have been developed that show tumor target specificity (as opposed to inc ...

Quantifying oceanic CO2 uptake and ocean acidification and understanding their impact on global climate and ocean ecology are key goals of NOAA’s climate change research programs. NOAA’s request for Development of a long-term Lagrangian pH and pCO2 drifter (SBIR Subtopic 8.3.1C) aims to address these goals by developing technology that measures both pCO2 and pH that can be widely deployed in t ...

This Small Business Innovation Research (SBIR) Phase II project proposes to develop fungal bioinsecticides for control of bark beetles in forestry. Bark beetles are difficult to control. With a life cycle mostly under tree bark, exposure to insecticides is limited to the short period when adults search for new host trees. Control of mountain pine beetle (MPB), one of the most damaging species, is ...

This Small Business Innovation Research (SBIR) Phase II project will adapt a photonics based signal processor to propel applications in extreme bandwidth spread-spectrum wireless communications. The signal processor prototype known as the spatial spectral holographic (S2H) extreme bandwidth analyzer / correlator (EBAC) will function as a correlating receiver for low probability of intercept (cover ...

This Small Business Innovation Research (SBIR) Phase II project will perfect a proprietary batch-scale processing technique for fabricating ultrahard and ultrasharp atomic force microscopy (AFM) tips. The new process involves two steps. First, chemical vapor deposition (CVD) is used to coat the tips with a chemically inert, highly conductive, and extremely hard material. Second, a patented process ...

This Small Business Innovation Research Phase II project proposes to develop and commercialize surface-engineered silicon anodes for use in lithium-ion batteries. Silicon has a ten fold greater charge capacity than graphite but its practical use as an anode material is hindered due to the mechanical problems associated with lithiation cycles (cracking, pulverization) and unwanted chemical reaction ...

This Small Business Innovation Research Phase I project advances a novel method to fabricate 3D IC interconnects. Physical and economical limitations for 2D scaling (Moore's Law) prevents further increase of integration density to improve the performance of integrated circuits (IC). These challenges have stimulated the development of 3D through-silicon via (TSV) technology (so called 'Mo ...

This Small Business Innovation Research (SBIR) Phase I project proposes to develop a new technology for monitoring aggregation in therapeutic protein solutions that will have wide-ranging impact in the pharmaceutical and biotechnology industries. Protein aggregation is a major problem across these sectors engaged in developing new protein pharmaceuticals. Protein aggregation can elicit immune resp ...

This Small Business Innovation Research Phase I project will address the three major factors currently limiting the global production of bamboo fibers for composites. First, all natural fibers absorb water from the air and direct contact from the environment. Second, the strength of natural fiber composites is less than that of composites reinforced with glass fibers. Part of this reduced strength ...

In the proposed effort, we will leverage this extensive experience and capabilities to realize a frequency agile mmW radiometer that can cover the range of DC-110 GHz and can be scaled to DC-200 GHz under Phase II. Ours is a photonic system that multiplies and up-coverts a low-frequency reference signal onto an optical carrier (laser) using EO modulation, then uses the modulation sidebands to inj ...