Award Data

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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Inhibition of retinoic acid metabolism for reversal of cognitive deficits in AD

    SBC: Dermaxon LLC            Topic: NIA

    DESCRIPTION (provided by applicant): Alzheimer's disease (AD) is a progressive and ultimately fatal neurodegenerative disease that affects more than five million people in the USA. Currently there is no cure for AD. Available medicines are aimed only at temporarily reducing symptoms and slowing down the progression of the disease. While many new compounds have been developed to treat AD, they ...

    STTR Phase I 2013 Department of Health and Human Services
  2. A Synthetic Human Cytomegalovirus Vaccine Platform

    SBC: TOMEGAVAX, INC.            Topic: NIAID

    DESCRIPTION (provided by applicant): The goal of this project is to synthesize, based on genomic sequence information, a human cytomegalovirus (HCMV) strain with demonstrated ability to establish persistent infection in sero-positive individuals. The resulting synthetic product will form the basis for the development of attenuated HCMV vaccines. Innovative synthetic biology methods will overcome ...

    STTR Phase I 2013 Department of Health and Human Services
  3. Biopsy and Freezing of Later-stage Mouse Blastocysts Using the Dracula Pipette

    SBC: GENESEARCH, INC.            Topic: NICHD

    DESCRIPTION (provided by applicant): Procedures on pre-implantation embryos are a cornerstone of much biomedical research; however in all cases, the procedures are very difficult and delicate, requiring exceptionally skilled technical experts and expensive equipment. The difficulties associated with these procedures often results in most such work being avoided by most biomedical research groups. ...

    STTR Phase I 2013 Department of Health and Human Services
  4. Position tracking and mobility assessment system for indoor monitoring of elders

    SBC: EMBEDRF LLC            Topic: NIA

    DESCRIPTION (provided by applicant): The goal of this project is to develop and evaluate a position tracking and mobility assessment system that will enable the elderly to live longer and more safely at home or in an assisted living facility. The ability to move is a critical function tat underlies the quality of life for the elderly. Changes in mobility such as speed of walking have been shown to ...

    STTR Phase II 2013 Department of Health and Human Services
  5. Novel Prebiotic Fiber as Targeted Dietary Management of Irritable Bowel Syndrome

    SBC: YELLOWSTONE SCIENTIFIC INSTRUMENTS            Topic: NIAAA

    DESCRIPTION: We propose to develop a new type of monitor to directly and simultaneously identify multiple biomarker metabolites in persons suspected of having been exposed to alcohol. The technology we plan to utilize is surface-enhanced Raman scattering(SERS), based on a well-known inelastic laser light scattering analytical technique for precise lab identification of organic compounds. Biomarke ...

    SBIR Phase I 2013 Department of Health and Human Services
  6. Instrumentation enabling a 16-fold decrease in oligonucleotide cost

    SBC: APDM, INC.            Topic: NIA

    DESCRIPTION (provided by applicant): Although balance and gait disorders are one of the most common and devastating chronic medical problems of older people, especially those with chronic neurological diseases, clinicians or clinical researchers do not measure balance and gait frequently, accurately, or sensitively. Our long-term goal is to develop and commercialize a unique system called the Hom ...

    SBIR Phase I 2013 Department of Health and Human Services
  7. Selective MRTF/SRF-Transcription Inhibitors: Novel Anti-fibrotics for IPF

    SBC: Promiliad Biopharma Incorporated            Topic: NIAID

    DESCRIPTION: Antibiotic resistance among common bacterial pathogens is a serious public health problem as it compromises our ability to treat infectious disease. The resistance problem is compounded by the relative lack of discovery of new antibiotics, especially those with novel mechanisms of action. Over the past several years Promiliad Biopharma has been developing new inhibitors that target ...

    SBIR Phase I 2013 Department of Health and Human Services
  8. A noninvasive optical imaging of retinal amyloid beta deposits in AD patients

    SBC: Oregon Center For Applied Science, Inc            Topic: NIDA

    DESCRIPTION (provided by applicant): Marital discord is a significant risk factor for a range of negative mental and physical health outcomes.1, 2 Individuals in unhappy relationships experience increases in stress, anxiety, functional impairment, and depressive symptoms3 and are at significant risk for substance abuse disorders.4-7 Furthermore, work loss associated with marital problems translate ...

    SBIR Phase I 2013 Department of Health and Human Services
  9. Integrin Targeted Therapy for the Treatment of Ovarian Cancer

    SBC: BIOSPEECH INC            Topic: NIDA

    Summary Sleep disordered breathing (SDB) is believed to be a widespread, under-diagnosed condition associated with detrimental health problems, at a high cost to society. The current gold standard for diagnosis of SDB is a time- consuming, expensive, and obtrusive (requiring many attached wires) sleep study, or polysomnography (PSG). The immediate objective of the proposed research is to develop a ...

    SBIR Phase I 2013 Department of Health and Human Services
  10. Human Monoclonal Antibody To Treat P. aeruginosa Infections in Cystic Fibrosis

    SBC: Advantage Silver Dental Arrest, LLC            Topic: NIDCR

    DESCRIPTION (provided by applicant): Topical fluorides have been the mainstay in the prevention of dental caries for decades. However, topical fluoride alone is not enough to thwart tooth decay in high-risk populations. The purpose of this Phase I application is to determine the technical and scientific feasibility of using a combination povidone-iodine (PVP-I)-5% sodium fluoride (NaF) varnish as ...

    SBIR Phase I 2013 Department of Health and Human Services
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