Award Data

This NIST Phase 1 SBIR effort will demonstrate the feasibility of low noise single photon up conversion using KTiOPO4 (KTP) or LiNbO3 (LN) or Stoichiometric LiTaO3 (SLT) periodically poled waveguides and an 1800nm pump for a high efficiency single photon detector. The key innovation is using low noise periodically poled waveguides with a long wavelength (1800nm) pump leading to higher efficiency s ...

This Small Business Innovation Research (SBIR) Phase II project aims to develop a novel Quality-by-Design (QbD) software platform directed at the needs of FDA's QbD initiative, a framework for innovative pharmaceutical development, manufacturing and quality assurance. QbD is implemented at four levels: process understanding; quality by design; monitor, predict and control; and continuous improveme ...

This Small Business Technology Transfer Phase I project will demonstrate the technical and commercial feasibility of an innovative aberration compensated focus control device for a revolutionary improvement in medical imaging. Currently, a variety of medical conditions are diagnosed and treated through in vitro imaging of suspicious tissues, requiring invasive, time-consuming biopsies. Several in ...

This Small Business Technology Transfer Phase I research project addresses the need for high-power ultrafast lasers from the visible to the mid-wave infrared spectral regions. This research will develop a highly innovative ultrafast laser system emitting sub-picosecond pulses that is based on unexplored coupling between stimulated Raman scattering, stimulated Brillouin scattering, and four-wave mi ...

This Small Business Innovation Research (SBIR) Phase II research project will implement a miniature information management system that is suitable to the access requirements for visually impaired users. Current information technologies for the visually impaired are slow and difficult to operate while holding a white cane or guide dog. Visually impaired people will benefit greatly from a hands-free ...

This Small Business Technology Transfer Phase I project will develop novel chemically and thermally stable, highly fluorinated mixed matrix polymeric membranes with high selectivity. The program's objective is to apply enhanced membrane separation as an alternative to distillation separations that deal with high temperature and aggressive chemicals. Distillation is a major separation process in th ...

This Small Business Innovation Research (SBIR) Phase II aims to prove the feasibility of creating a web-based mapping and visualization application for end-users in wildland fire management communities as an extension to the results of the Phase I work. By partnering with strategic vendors, the project will expand our current application to offer not only advanced remote-sensing data products and ...

This Small Business Innovation Research (SBIR) Phase I research project aims to develop novel nucleic acid labeling reagents that can be used in living cells to monitor gene expression. Instead of relying on labeling the molecules using fluorescently labeled bases, the proposed approach relies on adding the label to the terminal phosphates. This would have great advantage over existing methods a ...

The objective of this proposal is to demonstrate the feasibility of developing flex hoses for hydraulic and other piping system interfaces that can withstand high pressure environments, hydrodynamic, and other forces unique to deep submergence system operating environments. This hose and connecter system coined FlexiHOSE© proposed by MEI-Charlton, Inc. (MEIC) will meet the need of operating under ...

This Small Business Innovation Research (SBIR) Phase I project will develop new classes of advanced composites containing a recently discovered form of carbon, called the carbon nanocones (CNC) and carbon nanodisks (CND). The company has acquired exclusive rights from the Norwegian company that came up with this new class of materials, and this research will focus on taking advantage of the unique ...