Award Data

Project Summary Falls are the leading cause of injurieshospital visitsnursing home admissionsand reduced quality of life for people with neurological disordersAlthough there is consensus that impaired mobility is the basis for most fallsit is very di cult to evaluate these complex abilities outside a laboratory settingBrief clinical examinations do not accurately re ect dailyfunctional mobility in ...

PROJECT SUMMARY This program aims to develop a novel non opioid therapeutic for the treatment of pain that targets a subtype of the human voltage gated Na ion channel NaV Preliminary data indicate that SiteOneandapos s lead drug candidates may be more effective than opioids for treating certain types of pain and lack the side effects associated with opioid analgesics which include nausea ...

Abstract High risk human papillomaviruses HPV cause cervical cancer the second most common neoplasm among women globally and a large proportion of oropharyngeal cancers Although prophylactic vaccines to HPV are effective they have no therapeutic effect and thus do not benefit the millions of individuals already infected Thus there is both a medical need and a commercial opportunity for a HP ...

ABSTRACT Oral mucositis is a devastatingly painful inflammatory disease that frequently develops during cancer therapy and affects half a million people in the US The accompanying pain is so severe that patients often require narcotic pain medicines The clinical manifestations are ulcers in the mouth and gastrointestinal tract which are exacerbated by opportunistic infections Many patients al ...

DESCRIPTION provided by applicant In the manufacture of pharmaceutical compounds organic syntheses are often carried out in organic solvents These solvents must then be separated from high value intermediates and active pharmaceutical ingredients APIs in order to produce the final product medications Many intermediate compounds and APIs are thermally labile and thermal separation processes ...

Abstract Stroke is a leading cause of morbidity and mortality in the United States However less than of patients are eligible for the current approved interventions of tissue plasminogen activator or thrombectomy We seek to develop new therapeutics to reduce the extent of damage and functional impairment resulting from ischemic injury to the brain an area of significant unmet medical need ...

DESCRIPTIONprovided by applicantThis Phase I II Fast Track application is being re submitted under the NHLBI Small Business Topics of Special Interest for Fiscal YearHLSCertain life saving interventions such as cardiopulmonary bypassCPBextracorporeal membrane oxygenationECMOor ventricular assist deviceVADpump require the use of high dose heparin to maintain blood flow through the devices and or to ...

DESCRIPTION provided by applicant The objective of this Phase II project is to develop a commercially viable point of care Rapid HIV Incidence Assay the Asant Rapid HIV Recency Assay and establish its suitability for determination of recency of HIV infection in whole blood plasma serum specimens for epidemiological research and surveillance purposes from liquid blood serum or plasm ...

DESCRIPTIONprovided by applicantTraumatic brain injuryTBIis a leading cause of death and disability for children agedin the United StatesMore thanchildren and adolescents are hospitalized annually in the U Safter sustaining moderate severe brain injuries from motor vehicle crashesfallssportsand physical abusemore thanare seen in hospital emergency rooms and releasedTBI often results in significant ...

DESCRIPTIONprovided by applicantChildren who don t master the basics of literacye gphonological awarenessalphabetic awareness and letter writingvocabulary and oral languagein preschool risk failure in acquiring conventional reading skills later in elementary schoolNational Early Literacy PanelStorch et alConsidering that Head StartHSlargely serves children from minority or English learning backgro ...