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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

Displaying 1 - 10 of 4348 results
  1. Multimode Chiroptical Spectrometer for Nanoparticle Characterization

    SBC: Applied Nanofluorescence LLC            Topic: None

    This project will develop a new scientific instrument optimized for the advanced characterization of near-infrared fluorescent nanoparticles that can exist as left- or right-handed structures (enantiomers). Single-walled carbon nanotubes (SWCNTs) are the leading current example of such nanomaterials. Applied NanoFluorescence, LLC (ANF) proposes a novel multi-mode chiroptical spectrometer that can ...

    SBIR Phase II 2019 Department of CommerceNational Institute of Standards and Technology
  2. Gap-Free Model-Based Engineering for Manufacturing and Analysis: Digital Thread without Translation

    SBC: Nvariate, Inc.            Topic: None

    Modern Model-Based Enterprise / Engineering (MBE) systems rely on freeform surfaces built as complex combinations of geometric primitives to define engineered objects. Unfortunately, the intersection of freeform surfaces in MBE applications results in highly approximated solutions, degrading models that cost billions annually by US industry to fix. Current technology limits the abilities of users ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  3. A Portable Vibrio Cholerae Concentrator for Sensitive Pathogen Detection in Water

    SBC: Omnivis LLC            Topic: None

    This SBIR Phase I project proposes to develop an easy to use, inexpensive, and portable bacterial concentrator to enable more sensitive cholera pathogen (Vibrio cholerae) detection. Cholera affects communities across 41 countries, including Mozambique in 2019 after Cyclone Idai and Yemen in 2017. Current methods used to detect the cholera pathogen in water involves a 3 to 5-day procedure due to th ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  4. Advanced Manufacturing and Material Measurements Software Tool Weave ™ for the Acceleration and Automation of SEM Image Analysis in the Semiconductor Industry

    SBC: Sandbox Semiconductor Incorporated            Topic: None

    In this Phase I SBIR proposal, SandBox Semiconductor™ proposes to develop an Advanced Manufacturing and Material Measurements software tool called Weave ™ for accelerating and automating SEM image analysis for the semiconductor industry. During the development of a new manufacturing process line for a semiconductor device, tens of thousands of scanning electron microscopy (SEM) images are take ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  5. Nanomachine Device for Semiconductor Process Control Monitoring

    SBC: Xallent LLC            Topic: None

    Conventional characterization and test methods are increasingly ineffective when applied to structures less than 100 nanometers, causing challenges across R&D, process control and failure analysis. An increasing number of subtle defects become prominent drivers of failure as device size and operating margins decrease, e.g., processing anomalies in thin gate oxides, substrate problems related to do ...

    SBIR Phase I 2019 Department of CommerceNational Institute of Standards and Technology
  6. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo diseasemucopolysaccharidosis type IIIMPS IIIis a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologicslowing of developmentsevere behavioral problemsprogressive cognitive declinedementiaand decline in motor skills leading to immobilityunresponsivenessand deathWe have focused on MPS IIID caused by a deficiency of a ...

    SBIR Phase II 2018 Department of Health and Human Services
  7. Home Cage System for Fine Motor Assessments in Aging Rodent Models

    SBC: VULINTUS, INC.            Topic: NIA

    Project Abstract In this Phase I proposalVulintusIncproposes to develop and testOmniHomea wirelessself contained home cage system for assessing fine motor function in rodentsCurrent methods for longitudinally assessing skilled motor function in aging rodent models are labor intensivetime consuming to administer frequently over long timescalesand stressful to the animalThe proliferation of new rode ...

    SBIR Phase I 2018 Department of Health and Human Services
  8. Mobile Augmented Screening Tool to Increase Adolescent HIV Testing and Linkage to Care

    SBC: Digital Health Empowerment, Inc            Topic: NICHD

    ABSTRACTAdolescents face increased HIV riskinfrequent testinginconsistent linkage to careand a lack of prevention related knowledgeWe propose to address this by completing and evaluating the Mobile Augmented ScreeningMAStool to increase youth HIV testing via a tablet based intervention in clinical settingsand then use text messages to facilitate linkage to care for those who test positiveand deliv ...

    STTR Phase II 2018 Department of Health and Human Services
  9. Expansion of "youthful" mesenchymal stem cells from elderly individuals for autologous cell-based therapies

    SBC: Stembiosys, Inc            Topic: NIA

    SummaryAbstractOur group has recently licensed a technology enabling the identificationisolationand subsequent expansion ofyouthfulmesenchymal stem cellsMSCsfrom elderly individualsThis population is characterized by small size and expression of stage specific embryonic antigenSSEAPrior work indicates that smallSSEAsmallMSCsfunction in a manner similar to that of MSCs from young individualsMoreove ...

    SBIR Phase I 2018 Department of Health and Human Services
  10. Advanced Dynamic Clamp for Neuroscience

    SBC: Cytocybernetics Inc            Topic: 101

    The goal of this proposal is to develop a commercialplug and playuser friendlypowerful and reliable dynamic clamp systemto enable all neuronal electrophysiologists to be able to perform sophisticated dynamic clamp experimentswithout any requirement for programmingengineeringor mathematical modeling skillsWe will develop hardware and software specifically for neuroscience applicationsfocusing on th ...

    SBIR Phase I 2018 Department of Health and Human Services

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