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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

Displaying 1 - 10 of 5159 results
  1. Development and validation of therapy for mucopolysaccharidosis III

    SBC: Phoenix Nest Inc.            Topic: 103

    Project Summary Sanfilippo disease (mucopolysaccharidosis type III; MPS III) is a devastating neurodegenerative lysosomal storage disorder of childhood whose pathologic features are neurologic: slowing of development, severe behavioral problems, progressive cognitive decline, dementia, and decline in motor skills leading to immobility, unresponsiveness, and death. We have focused on MPS IIID cause ...

    SBIR Phase II 2018 Department of Health and Human ServicesNational Institutes of Health
  2. Development and Optimization of MNK Inhibitors for the Treatment of Neuropathic Pain

    SBC: 4E THERAPEUTICS, INC.            Topic: 104

    Abstract The goal of this project is to develop an optimized MNK inhibitor for neuropathic pain treatment. MNK is a kinase that phosphorylates eIF4E to control the translation of a distinct subset of mRNAs. Our focus on this target for neuropathic pain is grounded in evidence that MNK-eIF4E signaling is activated in nociceptors upon exposure to pain promoting cytokines and growth factors as well a ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  3. Knowledge Management System for Multilingual Health Content

    SBC: Transcendent International, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): The aim of the proposed project is to develop an advanced, web-based knowledge management system for the creation and distribution of multilingual, patient-oriented documents. The system provides a vast library of pre-translated documents and document templates for medical, educational, and administrative materials used in patient-care. System users will be abl ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Development of Inhaled Vancomycin for Treatment of MRSA Infections in CF

    SBC: SAVARA INC.            Topic: NHLBI

    DESCRIPTION provided by applicant Persistent respiratory methicillin resistant Staphylococcus aureus MRSA infections have become increasingly common in cystic fibrosis CF patients with a prevalence of almost in CF patients in the US This is concerning as MRSA positivity is associated with a faster decline of lung function and a years shorter median life expectancy compared to CF p ...

    SBIR Phase II 2013 Department of Health and Human ServicesNational Institutes of Health
  5. Preclinical Development of a Novel Therapeutic to Rejuvenate Aging Muscle Stem Cells and Enhance Muscle Strength and Function Post Hip Fracture

    SBC: RIDGELINE THERAPEUTICS LLC            Topic: NIA

    Muscle-aging is defined by progressive declines in mass and strength that poses a high risk for falls, fatal injury, and trauma-related fractures among older Americans (age 60+). Each year, rt30% of older adults suffer a fall, resulting in ~2.8 million traumatic fractures that significantly reduce mobility, independence, overall health, and quality of life for the elderly. Among fall-related injur ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
  6. A rationally-designed, live-attenuated RSV vaccine for the elderly

    SBC: Codagenix Inc.            Topic: NIAID

    PROJECT SUMMARY/ABSTRACT Respiratory syncytial virus (RSV) is a common respiratory virus that usually causes mild, cold-like symptoms. Most people recover within two weeks, but RSV is the most common cause of bronchiolitis and pneumonia in children under one year of age, and leads to hospitalization of ~177,000 adults aged 65 and older of which ~14,000 die annually. Despite many attempts, a vaccin ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  7. Human PSMA MAb Radioimmunotherapy for Prostate Cancer

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    Prostate cancer is the most common cancer of men in the United States with approximately 189,000 new cases and 30,000 deaths in 2002. Recurrent disease can be controlled temporarily with androgen ablation. However, almost all prostate carcinomas eventuall

    SBIR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  8. Improved AD/ADRD Assessment Sensitivities Using a Novel In-Situ Sensor System

    SBC: Birkeland Current LLC            Topic: NIA

    Project Summary/AbstractAccurate assessment of daily functions for individuals at risk for and with AD/ADRD, is fundamental to detection, diagnosis, and characterization of its progression and prescribed treatments. Current assessment techniques typically rely on non- continuous, discreet observations provided from a third party and covering single or limited performance domains. With significantl ...

    SBIR Phase II 2020 Department of Health and Human ServicesNational Institutes of Health
  9. Development of PSMA-based recombinant protein vaccines

    SBC: PROGENICS PHARMACEUTICALS, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Prostate cancer is the most common cancer of men in the United States with approximately 189,000 new cases and 30,000 deaths in 2002. Recurrent disease can be controlled temporarily with androgen ablation. However, alm

    SBIR Phase II 2004 Department of Health and Human ServicesNational Institutes of Health
  10. Finalizing and Testing an Online Therapist Training and Assistance Program to Facilitate Implementation of Comprehensive Behavioral Intervention for Tic Disorders (CBIT-Trainer)

    SBC: PSYC Tech, Ltd.            Topic: 104

    Abstract (Project 2R44MH111450-03A1) Tic disorders (TDs) are a class of neurodevelopmental disorders characterized by involuntary motor and vocal tics1 that affect 1%-3% of the population2 and cause substantial distress, interference and disability.3-9 Comprehensive Behavioral Intervention for Tics (CBIT) is an empirically-validated collection of behavioral tic management techniques that is now in ...

    SBIR Phase II 2021 Department of Health and Human ServicesNational Institutes of Health
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