Award Data

A low-cost fiber-based octave-spanning frequency comb system operating in the mid-IR region is proposed, which is based on femtosecond-Tm-fiber-laser-pumped supercontinuum generation in a mid-IR-transmitting dispersion-engineered fiber. An all-fiber femtosecond mode-locked Tm-doped fiber laser at 2 micron will be used as a seed source for mid-IR supercontinuum generation. A femtosecond soliton fib ...

An approach to make a long endurance UAV with an 18 hour endurance and large payload will be developed based on an existing, fielded capability present operationally deployed.  The system will be built from COTS equipment minimizing cost and allowing for rapid maintenance and upgrading of the system as technology develops.  The system will be fully autonomous through launch, mission flight and r ...

DESCRIPTION (provided by applicant): Delays in FDA drug approval are measured in lost lives (estimated to be hundreds of thousands over the last few decades) and increased costs to U.S. citizens for drugs that are eventually approved. One factor contributing to the delay in drug approvals is the widespread use of time-consuming and error-prone manual methods to deliver medical images (i.e. CT, MR, ...

This proposal will provide immediate decision support data, enabling appropriate and cost effective responses (shut down vs. continue) for training exercises/facilities. Specifically, the DoD requires the ability to “train as we fight and fight as we train”, however training is severely limited by visible emissions compliance in the current regulatory environment. Regulated facilities will hav ...

Rather than continuing to approach cyber security problems in a reactive fashion, ASD proposes to move to a proactive posture; anticipating and eliminating vulnerabilities while also being prepared to effectively and rapidly defend against attacks. Our approach collects data about the attacker as well as the attack, which it processes in real time. The data (observations) is then used by our prote ...

During the normal course of research, development, and testing by the DOD small quantities of environmentally hazardous waste propellants, explosives, and pyrotechnics (PEP) are produced.  The compliance costs and burden associated with open burn/open detonation operations are considerable, including permit fees, ground water, soil and air sampling, analysis and monitoring of environmental impact ...

Rapid detection of the total trihalomethanes (TTHM) in treated drinking water is essential for compliance with the Environmental Protection Agency’s (EPA) Stage 2 Disinfectants and Disinfection Byproducts (DBP) Rule, which limits the maximum contaminant level of TTHM in drinking water. The current detection method for TTHM determination involves sending samples to EPA certified laboratories for ...

DESCRIPTION (provided by applicant): The morbidity and mortality due to cardiovascular disease is attributed to the lack of significant replicative potential of adult mammalian cardiomyocytes. Thus myocyte loss in response to ischemic injury typically results in scar formation and a decline of cardiac function that is usually irreversible. The cessation of myocyte proliferation is associated with ...

DESCRIPTION (provided by applicant): Benign Prostatic Hyperplasia/Hypertrophy is a major health problem in the United States, with one-in-three men having urologic problems. Currently available treatment modalities include alpha-blockers that do not affect the underlying pathologic process, and 5-alpha-reductase inhibitors that have significant systemic side-effects. We have discovered that human ...

DESCRIPTION (provided by applicant): AndroBioSys, Inc. is dedicated to the development of human tissue-based in vivo tools capable of selecting better targeted agents for clinical trials by improved preclinical testing. AndroBioSys has developed the technology for reproducible implantation of primary xenografts of benign and malignant human prostate and kidney tissue. Xenografts have been establis ...