Award Data

Abstract Chronic kidney disease CKD is a progressive disorder affecting almost of the general population and this disease has shown a relentless growth over the past decades Patients with CKD have higher rates of hospitalization greater mortality shorter life expectancy and their healthcare costs are up to times more expensive than non CKD patients Thus treatments to slow halt ...

AbstractSince their clinical introduction overyears agocochlear implantsCIshave had a remarkable impact on patients experiencing moderate to profound hearing lossRecent advances in technology have driven the development ofhearing preservationimplants and procedures designed to preserve the residual acoustic hearing of patients while treating the damaged areas of the ear with an electrically stimul ...

Summary Single cell sequencing SCS is a disruptive new technology that offers an unprecedented ability to interrogate the genomics DNA RNA of single cells to understand the complex biologies of normal and diseased tissues SCS is not only important for basic research but also represents a next generation of diagnostic approaches particularly for cancer While multiple SCS platforms have bee ...

Bladder cancer is the fifth most commonly diagnosed cancer in the United StatesThree quarters of the nearlymen and women diagnosed with bladder cancer just this year will have a less aggressive form of the disease whichafter treatmentwill require frequent visits to the urologist for invasivepainful cystoscopy procedures for the remainder of their lifetimes to determine if the cancer has returnedAn ...

Project Summary Atrophic dry age related macular degeneration AMD is the leading cause of severe loss of vision for those over age Dietary supplements containing lutein and zeaxanthin are recommended by the NEI for those at risk of late AMD There has been a corresponding growth in demand for these two xanthophylls Lutein and zeaxanthin are currently sourced from marigolds grown mostl ...

PROJECT SUMMARY This application for a Phase I SBIR award represents a collaboration between Clinitech LLC and McLean Hospital Harvard Medical School to develop a wearable biosensor for detecting alcohol in the interstitial fluid of humans who have consumed alcohol Excessive use of alcohol accounts for much of the public health burden related to alcohol use disorders including fetal ...

Project Summary Abstract It is estimated that more than million people in the U S have Alzheimerandapos s disease AD The cardinal features of AD brain pathology are accumulation of A in insoluble plaques hyperphosphorylation of tau leading to its intracellular aggregation and as a consequence of one or both neuronal dysfunction Currently no disease modifying drugs exist for AD Jun N t ...

In this NIH Phase I SBIR project we propose to develop and evaluate a proof of concept for Mol a mobile STEM game to address difficult to learn topics in organic chemistry Our first module will focus on stereochemistry a notoriously challenging concept facing nearly million undergraduate students each year who are pursuing a healthcare career and another million biology and chemistry stude ...

AbstractA significant number of conscious hospitalized patients are unable to independently activate standard nurse call systemsand overof mechanically ventilated ICU patients need assistance to communicate with their caregiversBased on those estimates and the annual U Shospital discharge rateone can extrapolate that at leastmillion American patients may have required some form of assistive techno ...

Project Summary Abstract There is a tremendous need for tools that allow NIH sponsored investigators to easily share and disseminate data from brain imaging studiesAccess to large neuroimaging data sets is a critical aspect of learning about how the brain works both in health and diseaseMost typicallylarge data sets are collected by one investigatorused for a specific purposeand then archivedSomet ...