Award Data

The proposed study aims at accelerated development of Mo-Si-B-X (X=Ti, Zr, Hf, Re, Mn) alloys with an optimized balance of properties, via an approach of integrating thermodynamic modeling with experimental study.   On the basis of the Mo-Si-B-X (X=Ti, Zr, Hf) database developed in Phase I, a thermodynamic database of the Mo-Si-B-O-X (X=Ti, Zr, Hf, Re, Mn) system will be developed using the Calp ...

DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNT) are the most toxic substances known to humans causing respiratory failure upon poisoning. BoNT's lethality and ease of production has led to a category A bioterrorism agent designation for BoNT by the Department of Defense (DoD). Developing effective, post-exposure antagonists to BoNT is a top priority of the DoD. Despite their le ...

The goal of this SBIR is the enhancement of the current state-of-the-art combustion instability analysis tools.  The planned enhancement is focused on capturing the effects of injection element distribution and the inclusion of substantial film cooling and diluent injection.  These characteristics are extremely important in the design of high-pressure oxygen rich staged combustion (ORSC) engines ...

ORBITEC proposes to develop the Advanced Microwave Electrothermal Thruster (AMET) for use as one of the primary thrusters in the Dual-Mode Water Rocket Propulsion system.  The AMET uses an electrodeless microwave discharge to produce thrust from water vapor propellant, delivering specific impulse in excess of 800 seconds with a highly efficient process.  Microwave energy is introduced to a reson ...

DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as atherosclerosis. Whereas current anti-inflammatory drugs such as NSAIDs target secondary effects that are induced after inflammation is already est ...

CompuTherm, LLC proposes a pilot project to develop a modeling tool that can be used to assess the durability of environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) under combustion environment. The modeling tool includes a thermodynamic database for the gas phase, a thermodynamic database for the silicate system (EBCs), and a computer software package that deals with thermo ...

DESCRIPTION (provided by applicant): Current antifungal therapy is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Cryptococcus and the Zygomycoses. Neutropenic and immunocompromised patients, such as those with hematologic cancer, AIDS or an organ transplant, are ...

DESCRIPTION (provided by applicant): Cryptosporidiosis is a leading cause of diarrheal disease worldwide and is a category B biothreat agent. Two major species, Cryptosporidium hominis and Cryptosporidium parvum are responsible for over ninety percent of cases in man. C. parvum is zoonotic, with a reservoir in cattle, where it is an economically important cause of disease. There is currently no sp ...

DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

DESCRIPTION (provided by applicant): A hernia occurs when part of an internal organ bulges through a weak area of fascia, with most hernias occurring in the abdomen. Surgical hernia repair is one of the most commonly performed surgeries in the US. While using prosthetic mesh as a reinforcement has significantly improved surgical outcomes, the rate of hernia recurrence can be more than 50%. Current ...