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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Screening of glucocorticoid receptor small-molecule regulators using cognate site

    SBC: VISTAMOTIF LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. A Photoelectrocatalytic Device for Removing MTBE from Water

    SBC: AQUAMOST, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

    SBIR Phase I 2009 Department of Health and Human Services
  3. Pharmacological Impact of 3-Dimensional Extracellular Matrix on Tumor Cells

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There is a strong need in drug discovery for cellular assays that better predict human responses to drugs. A key technical hurdle has been the difficulty of incorporating 3-dimensional extracellular matrix into a powerful assay format that is compatible with the high throughput approaches used for early drug discovery. In this proposal we intend to develop the ...

    SBIR Phase I 2009 Department of Health and Human Services
  4. Enhanced ADP Immunoassay for Multimode Kinase Detection

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Kinases are the most intensively screened class of enzymes being targeted for therapeutic intervention because of their central role in regulating the function of other biomolecules. Strategies for developing selective kinase inhibitors are evolving rapidly, creating a demand for more flexible methods for measuring kinase activity in high throughput screening c ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. HTS Assays for Modulators of GPCR Signaling

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-psychotics, as well drugs used for neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The relatively recent discovery of a ...

    SBIR Phase II 2009 Department of Health and Human Services
  6. A microfluidic chemotaxis device for high content screening

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as atherosclerosis. Whereas current anti-inflammatory drugs such as NSAIDs target secondary effects that are induced after inflammation is already est ...

    SBIR Phase II 2009 Department of Health and Human Services
  7. Amphotericin B Analogs

    SBC: CENTROSE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Current antifungal therapy is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Cryptococcus and the Zygomycoses. Neutropenic and immunocompromised patients, such as those with hematologic cancer, AIDS or an organ transplant, are ...

    SBIR Phase I 2009 Department of Health and Human Services
  8. A Cell-based Assay for Botulinum Neurotoxin Detection and Development

    SBC: BIOSENTINEL, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Botulinum neurotoxins (BoNT) are the most toxic substances known to humans causing respiratory failure upon poisoning. BoNT's lethality and ease of production has led to a category A bioterrorism agent designation for BoNT by the Department of Defense (DoD). Developing effective, post-exposure antagonists to BoNT is a top priority of the DoD. Despite their le ...

    SBIR Phase I 2009 Department of Health and Human Services
  9. Parenting Your Young Child with Autism: A Web-Based Tutorial

    SBC: KOBAK, KENNETH A            Topic: N/A

    DESCRIPTION (provided by applicant): Autism is a neurodevelopmental disorder characterized by deficits in social reciprocity, verbal and nonverbal communication, and behavior. It is among the most prevalent of all developmental disabilities, with an estimated prevalence of 1 in 150. Early detection and intervention has been shown to improve long- term outcomes, including language functioning, cogn ...

    SBIR Phase I 2009 Department of Health and Human Services
  10. Web Based Therapist Training on Cognitive Behavior Therapy for Anxiety Disorders

    SBC: KOBAK, KENNETH A            Topic: N/A

    DESCRIPTION (provided by applicant): The need for evidence-based mental health treatments i.e., 'treatment based on the best available science or research evidence' has been stressed from scientific, ethical, and marketing perspectives. While empirical evidence supports both the efficacy and effectiveness of cognitive behavior therapy (CBT) for anxiety disorders, the demand for clinicians trained ...

    SBIR Phase I 2009 Department of Health and Human Services

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