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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Screening of glucocorticoid receptor small-molecule regulators using cognate site

    SBC: VISTAMOTIF LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  2. A Photoelectrocatalytic Device for Removing MTBE from Water

    SBC: AQUAMOST, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  3. Pharmacological Impact of 3-Dimensional Extracellular Matrix on Tumor Cells

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There is a strong need in drug discovery for cellular assays that better predict human responses to drugs. A key technical hurdle has been the difficulty of incorporating 3-dimensional extracellular matrix into a powerful assay format that is compatible with the high throughput approaches used for early drug discovery. In this proposal we intend to develop the ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  4. Enhanced ADP Immunoassay for Multimode Kinase Detection

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Kinases are the most intensively screened class of enzymes being targeted for therapeutic intervention because of their central role in regulating the function of other biomolecules. Strategies for developing selective kinase inhibitors are evolving rapidly, creating a demand for more flexible methods for measuring kinase activity in high throughput screening c ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  5. HTS Assays for Modulators of GPCR Signaling

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): More than 50% of drugs on the market target G protein-coupled receptors (GPCRs). Among the most important of these are drugs used to treat neurological disorders, such as pain relievers, antidepressants and anti-psychotics, as well drugs used for neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. The relatively recent discovery of a ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  6. A microfluidic chemotaxis device for high content screening

    SBC: Bellbrook Labs, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Leukocyte recruitment is central to inflammation, and there is intense focus on inhibiting the process both for chronic inflammatory disorders and for conditions where inflammation plays a contributory role, such as atherosclerosis. Whereas current anti-inflammatory drugs such as NSAIDs target secondary effects that are induced after inflammation is already est ...

    SBIR Phase II 2009 Department of Health and Human ServicesNational Institutes of Health
  7. High Performance Low Integration Cost Magnetometer System

    SBC: LEE, JENNA            Topic: AF083218

    An innovative data collection and analysis approach is proposed to enable body mount magnetometers for space application. In order to achieve high accurate magnetic field measurement in space, the magnetometer has to be located in a âmagnetically cleanâ place, where the magnetic field from spacecraft is negligible. Usually, the magnetometers are placed on deployable booms, so that the field sens ...

    SBIR Phase I 2009 Department of DefenseAir Force
  8. Amphotericin B Analogs

    SBC: CENTROSE LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Current antifungal therapy is limited by the types of drugs available to treat systemic infections due to emerging and comparatively rare fungi different from the common strains of pathogenic Candida, Aspergillus, Cryptococcus and the Zygomycoses. Neutropenic and immunocompromised patients, such as those with hematologic cancer, AIDS or an organ transplant, are ...

    SBIR Phase I 2009 Department of Health and Human ServicesNational Institutes of Health
  9. Accelerated Development of High-Performance Mo-Si-B-X Alloys via an Approach of Integrating Thermodynamic Modeling with Experimental Study

    SBC: Computherm, LLC            Topic: AF07T003

    The proposed study aims at accelerated development of Mo-Si-B-X (X=Ti, Zr, Hf, Re, Mn) alloys with an optimized balance of properties, via an approach of integrating thermodynamic modeling with experimental study.   On the basis of the Mo-Si-B-X (X=Ti, Zr, Hf) database developed in Phase I, a thermodynamic database of the Mo-Si-B-O-X (X=Ti, Zr, Hf, Re, Mn) system will be developed using the Calp ...

    STTR Phase II 2009 Department of DefenseAir Force
  10. A Modeling Tool for Predicting the Durability of Environmental Barrier Coatings (EBC) for Ceramic Matrix Composites (CMC)

    SBC: Computherm, LLC            Topic: AF083070

    CompuTherm, LLC proposes a pilot project to develop a modeling tool that can be used to assess the durability of environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) under combustion environment. The modeling tool includes a thermodynamic database for the gas phase, a thermodynamic database for the silicate system (EBCs), and a computer software package that deals with thermo ...

    SBIR Phase I 2009 Department of DefenseAir Force
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