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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until April, 2020.

  1. Screening of glucocorticoid receptor small-molecule regulators using cognate site

    SBC: VISTAMOTIF LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

    SBIR Phase I 2009 Department of Health and Human Services
  2. Novel approaches to extending glucose sensor lifespan

    SBC: AEGIS BIOSCIENCES, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

    SBIR Phase I 2009 Department of Health and Human Services
  3. Pandemic H5N1 vaccine containing recombinant H5 and a synthetic TLR4 agonist, GLA

    SBC: TRIA BIOSCIENCE CORP.            Topic: N/A

    DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

    SBIR Phase I 2009 Department of Health and Human Services
  4. A Photoelectrocatalytic Device for Removing MTBE from Water

    SBC: AQUAMOST, LLC            Topic: N/A

    DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

    SBIR Phase I 2009 Department of Health and Human Services
  5. Intelligent Microtome Instrumentation

    SBC: BARLOW SCIENTIFIC, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Fluorescent tagging of cells using dyes, fluorescent proteins, and quantum dots forms the basis for many powerful analytical methods in modern biology. Locating these cells within entire animals is necessary to study cell delivery, differentiation and gene expression. The Phase II SBIR research is developing an intelligent microtome to provide the means to loca ...

    SBIR Phase II 2009 Department of Health and Human Services
  6. Online Training in the Fundamentals of Eating Disorders Treatment

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training program to aid in the dissemination of evidence-based Eating Disorder (ED) treatments (e.g., Cognitive Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa (BN) and Binge Eating Disorder (BED) . The current ...

    SBIR Phase I 2009 Department of Health and Human Services
  7. DBT Skills Training Central

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training aid for Dialectical Behavior Therapy (DBT) skills providers treating borderline personality disorder and substance dependence (BPD-SUD) individuals. The primary purpose of the eventual product, DBT Skills Central, is to help ...

    SBIR Phase I 2009 Department of Health and Human Services
  8. Computer-Based Training in Behavioral Activation Treatment for Depressed Adults

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase II Small Business Innovation Research (SBIR) grant application to support the further development of an innovative, online training program to aid in the dissemination of Behavioral Activation (BA), a therapy for depression. The current application represents a continued cooperative partnership between the small business, Behavioral Tech Researc ...

    SBIR Phase II 2009 Department of Health and Human Services
  9. Online Training in the Principles and Procedures of Exposure Therapies

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): This is a Phase II Small Business Innovation Research (SBIR) grant application to support the further development of an innovative, online training program to aid in the dissemination of exposure therapies (ETs) for anxiety disorders. ETs have consistently and robustly been found effective in the treatment of anxiety disorders. However, these evidence-based tre ...

    SBIR Phase II 2009 Department of Health and Human Services
  10. Utilizing Mobile Technology for DBT Skills Generalization with BPD-SUD Clients

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: N/A

    DESCRIPTION (provided by applicant): Substance use disorders (SUD) co-occurring with borderline personality disorder (BPD) pose serious and complex public health problems. Dialectical Behavior Therapy for Substance Abusers (DBT) is an efficacious psychosocial treatment for substance dependent individuals with BPD (Linehan, 1993a, b; Lynch et al., 2007). This is a Phase I Small Business Innovation ...

    SBIR Phase I 2009 Department of Health and Human Services

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