Award Data

DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

Concentrated animal feeding operations (CAFOs) continue to experience every increasing pressure regarding nutrient overloads and air and water environmental concerns on their farms. Additionally the producers are subject to every growing and skyrocketing fuel and fertilizer costs. This USDA SBIR Phase I project aims to demonstrate an innovative technology that recovers ammonia nitrogen from CAFO a ...

DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

DESCRIPTION (provided by applicant): Fluorescent tagging of cells using dyes, fluorescent proteins, and quantum dots forms the basis for many powerful analytical methods in modern biology. Locating these cells within entire animals is necessary to study cell delivery, differentiation and gene expression. The Phase II SBIR research is developing an intelligent microtome to provide the means to loca ...

DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training program to aid in the dissemination of evidence-based Eating Disorder (ED) treatments (e.g., Cognitive Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa (BN) and Binge Eating Disorder (BED) . The current ...

DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training aid for Dialectical Behavior Therapy (DBT) skills providers treating borderline personality disorder and substance dependence (BPD-SUD) individuals. The primary purpose of the eventual product, DBT Skills Central, is to help ...

DESCRIPTION (provided by applicant): This is a Phase II Small Business Innovation Research (SBIR) grant application to support the further development of an innovative, online training program to aid in the dissemination of Behavioral Activation (BA), a therapy for depression. The current application represents a continued cooperative partnership between the small business, Behavioral Tech Researc ...

DESCRIPTION (provided by applicant): This is a Phase II Small Business Innovation Research (SBIR) grant application to support the further development of an innovative, online training program to aid in the dissemination of exposure therapies (ETs) for anxiety disorders. ETs have consistently and robustly been found effective in the treatment of anxiety disorders. However, these evidence-based tre ...