Award Data

High fidelity, large scale simulations of complex systems pose a very difficult situation to the scientist trying to understand the physical domain and characteristics of their system. Often, it is impossible to manually search through the data that can come out of these simulations, which may range from Gigabytes to Terabytes. Furthermore, it may be impossible to visualize the multi-dimensional i ...

Providing commanders with accurate, on-the-spot, clear, concise, usable information wins battles and saves lives. With incoming information from many heterogeneous sources, the focus has been primarily on determining what information to present, and visual ways of communicating the information. There has been less research on what makes information actionable, or on what additional communication c ...

There is a need for a next-generation integrative decision support system for Space Control operations. This next-generation system should provide high-level capabilities for managing case files containing evidence, expert opinions, and data relationships. The system should enhance operator awareness by highlighting salient aspects of the case file, critical relationships, and confidence assessmen ...

The monitoring of multiple UAV video sources is challenging, in part, due to the poor quality of the video received.  Significant video degrading is caused by clouds, haze, and dust in the atmosphere; jitter and blurring from the UAV platform motion; and low video resolution due to sensor characteristics and high altitude flying. Higher quality video would alleviate much of the challenge for the ...

DESCRIPTION (provided by applicant): Glucocorticoid receptor (GR) is a member of the nuclear receptor (NR) superfamily that is instrumental in regulating genes involved in inflammation and immunosuppression and represents a major therapeutic target for asthma, arthritis, lupus, and other chronic disorders. A major challenge in GR drug design is the necessity to enhance GR-mediated anti-inflammator ...

DESCRIPTION (provided by applicant): Long term transcutaneous devices such as catheters; require patients to endure extended skin breaches (wounds) that can be difficult to manage clinically, i.e. infection and inflammation. These complications not only shorten device lifespan, but also compromise patient health. In the case of short-term commercial transcutaneous glucose sensors, FDA has approved ...

DESCRIPTION (provided by applicant): H5N1 is a highly pathogenic avian influenza virus that can cause severe disease and death in humans. H5N1 is spreading rapidly in bird populations world-wide and there is great concern that this virus will begin to transmit between people and cause a global pandemic catastrophe. Vaccines are the cornerstone strategy for combating avian flu but there are numerou ...

DESCRIPTION (provided by applicant): There are currently between 500,000 and 2.5 million leaking underground fuel storage tanks in the United States. Soluble organic compounds that enter the groundwater from these tanks can be a major hazard to public health and the environment. Two contaminate classes are of particular concern: (1) BTEX fuel additives consisting of benzene, ethyl benzene, toluene ...

DESCRIPTION (provided by applicant): Fluorescent tagging of cells using dyes, fluorescent proteins, and quantum dots forms the basis for many powerful analytical methods in modern biology. Locating these cells within entire animals is necessary to study cell delivery, differentiation and gene expression. The Phase II SBIR research is developing an intelligent microtome to provide the means to loca ...

DESCRIPTION (provided by applicant): This is a Phase I Small Business Innovation Research (SBIR) grant application to support the development of an innovative, online training program to aid in the dissemination of evidence-based Eating Disorder (ED) treatments (e.g., Cognitive Behavioral Therapy and Interpersonal Psychotherapy for Bulimia Nervosa (BN) and Binge Eating Disorder (BED) . The current ...