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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. A novel DC-targeting non-integrating lentivector vaccine for HIV infection

    SBC: TRIA BIOSCIENCE CORP.            Topic: NIAID

    DESCRIPTION (provided by applicant): Despite two decades of persistent research on prophylactic and therapeutic immunization against HIV, an effective vaccine-based solution to the HIV pandemic has remained elusive. However, the last few years have provided important insights into the type of immune response that would be required for an effective HIV vaccine. For instance, in studies of natural H ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  2. Online PCT Training for Clinicians

    SBC: BEHAVIORAL TECH RESEARCH, INC.            Topic: NIMH

    DESCRIPTION (provided by applicant): Panic attacks (PA) impact about 23% of adults in community samples. Panic disorder with or without agoraphobia (PDA) tends to be a chronic condition with a lifetime prevalence of 4.7%. When untreated, panic disorder (PD) often leads to debilitating problems, with severe financial and interpersonal costs. Panic Control Treatment (PCT) is an efficacious treatment ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  3. Intramolecular Immunoassay for Probing Paracrine Signaling

    SBC: Bellbrook Labs, LLC            Topic: NIGMS

    DESCRIPTION (provided by applicant): Key elements of tumorigenesis are driven by paracrine signaling between stromal and epithelial cells within the context of the extracellular matrix. Unfortunately, the cellular assays used for drug discovery typically rely on a single cell type grown as a monolayer, and this aspect of tumor biology very poorly. This may be one factor contributing to the low suc ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  4. A Highly Miniaturized Device For Fully Differentiated, Primary Cell Models of Air

    SBC: Bellbrook Labs, LLC            Topic: NHLBI

    DESCRIPTION (provided by applicant): There is a strong need for more predictive cellular assays that better represent the tissue that is under investigation. For airway epithelia such a model exists, and uses primary cells grown at an air liquid interface (ALI). A key technical hurdle has been the large cell numbers that are needed to run these assays using cell culture inserts. This method is als ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  5. Development of targeted photodynamic therapy for treatment of dental caries

    SBC: C3 JIAN, INC.            Topic: NIDCR

    DESCRIPTION (provided by applicant): Dental caries (tooth decay) is one of the most prevalent and costly infectious diseases in the United States. The oral cavity harbors a complex microbial community consisting of over 600 different non-harmful/commensal microbial species together with a limited number of pathogenic bacteria, including the major etiological agent of dental caries, Streptococcus ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  6. Not Available

    SBC: STEMINA BIOMARKER DISCOVERY, INC            Topic: NCI

    Brain tumor stem cells (BTSCs) are a subset population within tumors that are widely believed to be responsible for tumor recurrence, due to their ability to self-renew, differentiate, migrate, and initiate tumor propagation. Given these unique features, the selective targeting of BTSCs with novel therapies may prevent tumor recurrence. Stemina will progress efforts to determine BTSC biomark ...

    SBIR Phase II 2010 Department of Health and Human ServicesNational Institutes of Health
  7. Generation of a Novel Therapeutic for Prostate Cancer Bone Metastasis

    SBC: CISTHERA, INC.            Topic: NCI

    DESCRIPTION (provided by applicant): Prostate cancer is the third most common form of cancer in the US with an estimated 186,320 new cases in 2008 and 28,660 associated deaths. There are no curative treatments for metastatic prostate cancer. The annual cost of treating prostate cancer in the US is approximately 8 billion dollars. The end points of this proposal are to generate a new drug candidate ...

    SBIR Phase I 2010 Department of Health and Human ServicesNational Institutes of Health
  8. A Modeling Tool for Predicting the Durability of Environmental Barrier Coatings (EBC) for Ceramic Matrix Composites (CMC)

    SBC: Computherm, LLC            Topic: AF083070

    CompuTherm, LLC proposes a pilot project to develop a modeling tool that can be used to assess the durability of environmental barrier coatings (EBCs) for ceramic matrix composites (CMCs) under combustion environment. This modeling tool is a package that integrates thermodynamic databases for the gas phase and silica-oxide EBC systems, and robust computer software dealing with complicated systems ...

    SBIR Phase II 2010 Department of DefenseAir Force
  9. Azimuthal-Current Drive (ACD) Plasma Beam for Space Debris Mitigation

    SBC: EAGLE HARBOR TECHNOLOGIES, INC.            Topic: N093223

    The proposed innovation seeks to take advantage of a recently developed highly collimated, high density plasma system which has applications for remote space debris removal. The Azimuthal-Current drive (ACD) Plasma Beam System produces a highly directed, intense plasma beam which can be shown to be effective in removing small space debris by imparting directed energy to small objects providing eno ...

    SBIR Phase I 2010 Department of DefenseAir Force
  10. Ultrahigh Definition OLED Microdisplay (UDM)

    SBC: eMagin Corporation            Topic: AF093021

    Development of an Ultrahigh definition (>5 megapixel) active matrix OLED microdisplay with high dynamic range and refresh rate, and which provides 20/20 acuity with a digital near-eye visualization system, has the potential to significantly increase warfighter effectiveness without requiring compromises between resolution, field of view and digital capability. Active matrix OLED has been proven to ...

    SBIR Phase I 2010 Department of DefenseAir Force
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