Award Data

High performance infrared photodetectors and light sources that span infrared wavelengths from 2 to 14 microns and beyond are critical to DoD. At the longer wavelengths these devices demand stringent cooling requirements, which add size, weight, power consumption and cost. In this program we are developing tunnel diodes based on epsilon near zero (ENZ) metal-insulator-metal (MIM) rectenna structur ...

A critical SWAP-C requirement for future IR systems is the ability to operate at room temperature (RT). While some IR devices such as microbolometers operate at RT, their speed and detectivity is compromised. Therefore, the functionality of IR platforms can still be improved. Tunnel diodes based on epsilon near zero (ENZ) metal-insulator-metal (MIM) rectenna structures have the potential of disrup ...

SUMMARY Diabetic retinopathy (DR) is a leading cause of blindness in the United States. Currently, most treatments for DR are only applicable at the late stage and are invasive. Anti-VEGF (vascular endothelial growth factor) agents have achieved impressive therapeutic effects against DR and neovascularization (NV). However, 40% of patients with DR have inadequate responses to the treatment. Given ...

AbstractPolyfluoro- and perfluoroalkyl substances (PFAS) are a group of highly fluorinated alkanes. Members of this family are known to be persistent and bioaccumulative. PFAS are associated with unfavorable health outcomes in human and animal models. Several public health agencies as well as scientists have published articles that indicate the presence of PFAS in human blood, serum, milk, cord bl ...

PROJECT SUMMARY The overall goal of this application is the translation of a new crosslinkable bone void filler that will allow surgeons to better heal patients after craniofacial bone loss. The bone void filler designed is unique in that it can be implanted as a paste then quickly transition to a solid after initiation with blue light. The ability to transition into a solid after placement is uni ...

Biolytx Pharmaceuticals Corp. is developing a peptide, BP001, derived from the human endogenous host defense protein CAP37, as a novel multi-target ophthalmic product for corneal infections and injuries. The standard-of-care for corneal infections is topical administration of antibiotics that may be accompanied by topical steroids, to limit the destructive effect of the resulting corneal inflammat ...

Perfluorinated alkyl substances (PFAS), nicknamed “Forever Chemicals”, are extensively used in industries and firefighting applications as a component of aqueous film forming foams (AFFFs). Because members of this class of chemicals are persistent, they are prevalent in nature and are detected across the globe in water, air, soil, plants, animals, and even in human milk and blood. They are tox ...

SUMMARY Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly in the U.S. Wet AMD accounts for up to 90% of vision loss in AMD patients, which is characterized by choroidal neovascularization (CNV). Currently, no cure exists for AMD, and available drug therapies focus on intravitreal injection of anti- vascular endothelial growth factor (VEGF) agents. These anti-V ...

Project Summary / Abstract According to the National Eye Institute (NEI), early detection and timely treatment can reduce the risk of severe vision loss from diabetic retinopathy (DR) by 95%. Yet, DR remains the leading cause of blindness among American adults. By 2030, 54.9 million Americans are expected to have diabetes. The prevalence of vision-threatening diabetic retinopathy (VTDR) among peop ...

Abstract: Pancreatic ductal adenocarcinoma (PDAC) is one of the most devastating human cancers. It is the fourth leading cause of cancer-related deaths in the U.S. annually, with a lt7% 5-year survival rate. Despite FDA-approved therapeutic regimens and marked improvements in medical and surgical care, no significant impact on PDAC patient survival has been achieved. In 2017, some 53,000 Americans ...