Award Data

"A shock mitigating suspended seat which places the Special Forces Operator in an optimal ergonomic position will be developed for use in small Maritime Combatant Craft. It will feature an actively controlled shock absorber to optimize the suspension for abroad range of operator weights and sea states. In Phase I, a conceptual design of all the major components as well as the architecture for bo ...

Our nation faces increasing challenges in meeting the special needs of elderly and disabled individuals. Non-ambulatory persons with visual impairment, diminished upper-body mobility, spasticity/tremors, memory/attention deficits and other problems may require extraordinary care measures because they can operate neither powered nor manual wheelchairs successfully. Current state-of-the-art motorize ...

DESCRIPTION (provided by applicant) This project will develop an artificial intelligence to provide the core functionality for virtual reality and computer based treatments for anxiety disorders. The use of artificial intelligence offers a number of advantages over existing treatments: (1) artificial intelligence provides personalized treatment - using multiple real time physiologic and subjective ...

DESCRIPTION (provided by applicant): The primary objective is to determine the relationship between clinical growth in pubertal girls and boys and shifts in the irregularity of underlying growth hormone (GH) secretory patterns. Novel clarifications of this time-evolution could be significant in determining the proper timing of hormone replacement therapies in pathophysiological settings such as T ...

The goal of this effort is to develop a novel label-free detection technology for application to protein microarrays. The objective of the Phase I is to build a breadboard prototype to characterize the performance of this new approach and to establish feasibility. The technology is based on a multilayer grating-coupled (MGR) evanescent wave sensing method with the potential to provide highly mul ...

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A microarray-based system for label-free, high throughput protein expression in profiling in very small volumes of tissue or blood (approximately 10 mL) is proposed. The system will consist of an instrument, and a proteomic biosensor chip integrated into a fluidics cartridge. It utilizes a novel grating-coupled surface plasmon resonance (GC-SPR) imaging technology that will enable measurement of t ...

DESCRIPTION (provided by applicant)The broad objective of this Fast Track project is to develop and commercialize a versatile and inexpensive CCD-based system for microarray imaging and quantification. A differentiating feature of this system will be the capability to perform time-gated imaging, which will provide the benefits of effective background suppression on certain substrates such as membr ...

The overall goal of this project is to develop new, high performance stationary phases for chiral separations. These phases are copolymers consisting of approximately 50 mole-% crosslinker and 50 mole-% chiral selectors. They are based on new co-polymer phases developed by Fenris Technology Research, Inc. These new materials have demonstrated chromatographic efficiencies that are equivalent to sil ...

DESCRIPTION (provided by applicant): The pharmacological efficacy of a protein often depends on the protein's glycosylation structure, and successful manufacturing relies on host systems that produce glycoforms similar to those in humans. The overall objectives of this project are to develop tools for the metabolic engineering of fungal glycosylation pathways and to use these tools toward the cre ...