Award Data

Abstract: Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases in children and adults associated with diet-associated hepatic lipid accumulation (steatosis), and is a common hepatic manifestation of obesity and metabolic syndromes including diabetes. Modulation Therapeutics is developing a stearoyl- coenzyme A desaturase-1 (SCD1) inhibitor for the treatment of NAFLD a ...

Abstract: Developing a Digital Training and Assessment Platform to Disseminate a Successful NIH- Supported College Preparation Model for Diversifying the U.S. Biomedical Workforce This Phase 1 SBIR project will design and test a digital training and assessment platform—HSTA Hatch—to help geographic regions outside West Virginia (WV) establish workforce development programs for grade 9-12 youth ...

PROJECT SUMMARY Metabolic reprogramming plays a critical role in carcinogenesis, in part due its ability to promote immunesuppressive properties within tumors. It remains unclear whether inhibition of fatty acid metabolism in tumorsaffects their immunogenicity. We show that inhibition of stearoyl CoA desaturase 1 (SCD1), the rate limitingenzyme involved in fatty-acid synthesis converting saturated ...

NextGen Federal Systems (NextGen), a Small Business Concern (SBC), is excited to propose a powerful software package, coupled database, and a machine-learning (ML) workflow to support streamlined evaluation and research-to-operations (R2O) of space weather ML models and techniques. In response to the NOAA Effect of Space Weather subtopic (NOAA SBIR 9.5), we propose the Machine Intelligence for Spa ...

The original Phase IIb proposal addressed problems in analyzing, accessing and communicating increasingly large 3D and 4D image sets in neuroscience. This supplement request is motivated by two unforeseen developments since submission and review of the original application. The requested activities are necessary to maintain the high overall impact of the project. First, due to larger than expected ...

AbstractTens of millions of rodents are used for scientific research yearly. These animals are necessary for disease model testing and are essential for pre-clinical development of human therapeutics. Despite this great need, the current best practice for management of mouse colony health relies on manual checking, which is stressful for animals, time consuming and error-prone. While advances have ...

Abstract/Summary Over the last 20 years, mass spectrometry (MS) instrumentation has advanced at a remarkable clip. Improvements in ion focusing, mass analyzer, and ion detection regions have greatly enabled the study of protein molecules in their native state (native MS). One area that has remained relatively constant is the ionization source where nanoelectrospray ionization (nESI) has remained t ...

We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and joints. Inflammatory arthritis disables thousands of people each year. It occurs in children and adults, after trauma and infections but most cases are idiopathic. Millions of adults live with chronic RA, which has similar features. Inflammatory arthritis often r ...

Over the past 15 years, new imaging technologies and methods for high throughput imaging have revolutionized structural biology by extending the resolution and scale of collected images in 3 dimensions. The resulting image volumes are more typically hundreds of GB to even tens of TB and in some cases approach PB sizes. These file sizes pose challenges for image acquisition, image analysis, and com ...

We are working on a new approach to treating acute arthritis based on a common pathway in the cellular infiltrates that damage bones and jointsInflammatory arthritis disables thousands of people each yearIt occurs in children and adultsafter trauma and infections but most cases are idiopathicMillions of adults live with chronic RAwhich has similar featuresInflammatory arthritis often requires trea ...