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The Award database is continually updated throughout the year. As a result, data for FY19 is not expected to be complete until June, 2020.

  1. Extended release formulation of a new IOP lowering drug for improved treatment of glaucoma

    SBC: Oculo Therapy, LLC            Topic: NEI

    Glaucoma is the leading cause of irreversible blindness in the worldElevated intraocular pressureIOPis the most significant risk factor contributing to death of retinal neurons and resulting visual field loss in primary open angle glaucomathe most common form of glaucomaThe current standard of care for glaucoma includes IOPlowering medications delivered topically as eye dropswhich decrease the vol ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  2. Identifying the precursor to oxytocin-induced uterine tachysystole by monitoring with uterine EMG

    SBC: PreTel, Inc.            Topic: NICHD

    Approximatelyof all women in the USoverannuallyare exposed to IV oxytocin at some point during labor to increase the frequency and strength of uterine contractionsOxytocin is classified as a high alert medication requiring clinical vigilanceOxytocin is generally safebut adverse outcomes arise when contractions become too frequenta condition called tachysystoleTachysystole is associated with fetal ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  3. Expanding the Tool Box: Environmental Metabolomics Improves Decision Making and Management of Contaminated (Superfund) Sites

    SBC: Microbial Insights, Inc.            Topic: NIEHS

    Project Summary Abstract Metabolomics is a relatively novel Molecular Biological ToolMBTwhich employs highly sensitive instrumentation to obtain a measure of all small organic molecules present in a biological sampleContemporary MBTs rely on quantitative PCR and measure the presence and abundance of keystone bacteriae gDehalococcoidesinvolved in the detoxification of priority contaminants such as ...

    SBIR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  4. Non-Invasive Venous Waveform Analysis (NIVA) in patients with Heart Failure (HF)

    SBC: Volumetrix, LLC            Topic: NHLBI

    Volume overloadcongestionoccurs in patients with heart failureHFand is the leading cause of hospitalization in the elderly worldwideUnfortunatelyclinical signs and symptomslaboratory valuesand existing diagnostic tools are unreliable in providing accurate assessment of volume statusUsing a unique physiologic signalNon Invasive Venous waveform AnalysisNIVAVoluMetrix has developed a proprietary devi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  5. Enabling dexterous surgery at the tip of a flexible endoscope: A low-cost, disposable, steerable sheath.

    SBC: EndoTheia, Inc.            Topic: NIBIB

    Project Summary AbstractThe objective of this proposal is to perform proof of concept experiments for a new thin walledsteerable sheath that can pass through a standard colonoscope port and dexterously maneuver surgical instruments at its tipClinical significance comes from the fact that overpatients per year in the USA have unnecessaryinvasive surgery to remove a section of their colonClinical li ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  6. Autoscreen: An innovative e-health solution for early identification of Autism Spectrum Disorder Phase II

    SBC: Adaptive Technology Consulting, LLC            Topic: NIMH

    PROJECT SUMMARY Early accurate identification and treatment of young children with Autism Spectrum DisorderASDrepresents a pressing public health and clinical care challengeGiven mounting evidence that earlyaccurate diagnosis of ASD is possible and that very young children who receive intervention can demonstrate substantial gains in functioningcurrent American Academy of Pediatrics practice guide ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  7. Fully Human Antibody Combinations for the Prevention of Seasonal Influenza Infection

    SBC: IDBiologics, Inc.            Topic: NIAID

    Our overarching goal is to develop a monoclonal antibody based product for the prevention of seasonal influenza in high risk patientsIt is estimated there aredeaths annually related to seasonal influenza worldwideIn the United Statestheinfluenza season was classified a high severity season withdeathsandhospitalizations attributed to influenzaserving as a reminder of the continued severity of influ ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health
  8. Multifunctional Semi-Powered Ankle Prosthesis: Phase II

    SBC: Synchro Motion LLC            Topic: NICHD

    PROJECT SUMMARY A conventional prosthetic ankle consists of a carbon fiber ankle foot complex that is nominally configured to a neutral positionThese prostheses generally work well for level walking and level ground standingbut lack the adaptability to explicitly accommodate other terrain or locomotion activitiessuch as slope walkingslope standingand stair ambulationAs suchcommon activities with a ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  9. Expanding the throughput of real-time toxicological screening of cardiac differentiation by expressing a synthetic luciferase/luciferin genetic pathway in iPSCs

    SBC: 490 BIOTECH INC            Topic: NIEHS

    Expanding the throughput of real time toxicological screening of cardiac differentiation byexpressing a synthetic luciferase luciferin genetic pathway in iPSCs Project Summary This Small Business Innovation ResearchSBIRPhase II project proposes to develop and validate autonomously bioluminescent induced pluripotent stem cellsiPSCsfor use in continuously data producingreagent freeand real time toxi ...

    SBIR Phase II 2019 Department of Health and Human ServicesNational Institutes of Health
  10. Mobile-phone integrated rapid diagnostic tests to improve antibiotic stewardship

    SBC: PragmaDx, Inc.            Topic: NIAID

    PROJECT SUMMARYAn estimatedbillion antibiotic prescriptions were filled in the US fromDespite a national antibiotic education campaignapproximatelyof antibiotic prescriptions are unnecessaryAs a result of the over prescription of antibioticsthere is a current and pressing public health need for improved antibiotic stewardshipCompounding this problem are new modalities of healthcare like telemedici ...

    STTR Phase I 2019 Department of Health and Human ServicesNational Institutes of Health

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