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The Award database is continually updated throughout the year. As a result, data for FY24 is not expected to be complete until March, 2025.

Download all SBIR.gov award data either with award abstracts (290MB) or without award abstracts (65MB). A data dictionary and additional information is located on the Data Resource Page. Files are refreshed monthly.

The SBIR.gov award data files now contain the required fields to calculate award timeliness for individual awards or for an agency or branch. Additional information on calculating award timeliness is available on the Data Resource Page.

  1. Harmony AI: State of the Art Natural Language Processing for Genetic Engineering

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Computational techniques for gene engineering, such as codon optimization, use synonymous codon changes to increase protein production. Applications for these computational gene optimizations include recombinant protein drugs, nucleic acid therapies, and mRNA vaccines. Although codon optimization increases protein production in certain systems, synonymous changes to a gen ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  2. A synergistic in vitro-in silico model of the placental barrier for predicting fetal exposure and toxicity of xenobiotic compounds

    SBC: CFD RESEARCH CORPORATION            Topic: NICHD

    The placenta is one of the least understood organs of the human body. Acting as a barrier between mother and fetus, the placenta mediates transport of oxygen, nutrients, fetal waste products and other compounds present in maternal circulation. Full term placental explants are currently the most widely used models for assessing transport and barrier function. Unfortunately, these models are depende ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  3. Design of a bioactive mimetic of soluble klotho for the treatment of chronic kidney disease

    SBC: Alpha Young LLC            Topic: 400

    PROJECT SUMMARY Over 37 million individuals in the U.S. have chronic kidney disease (CKD) and are at high risk to die from cardiovascular complications. While great strides have been made to improve CKD care and dialysis access, minimal advances have been made in drug development to stall or reverse kidney damage and associated pathologies. Currently, therapeutic options to prevent cardiovascular ...

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  4. Harmony AI: Natural Language Processing Enabling Advanced Biomanufacturing

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Project Summary/Abstract: Recombinant proteins have a wide range of applications, from pharmaceutical products, drug discovery, protein-based polymers for drug delivery, antibodies enzymes, and sustainable technologies such as textiles and vegan food production such as the impossible burger. Towards meeting these increased demands by replacing batch culture with continuous culture reduces overhead ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  5. Bionanomatrix coating to enhance antibacterial effects while reducing inflammation of knee joint implants

    SBC: ENDOMIMETICS LLC            Topic: NIAMS

    Osteoarthritis (OA) is a degenerative joint disease that affects over 32 million individuals in the United States, causing debilitating joint destruction and chronic joint pain, stiffness, and physical impairment. To restore and improve the patient’s quality of life, total knee arthroplasty (TKA) is the most common surgical intervention performed for OA to replace the compromised joint with arti ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  6. An Inhaled Microbiome-Targeted Biotherapeutic for Treatment of COPD

    SBC: ALVEOLUS BIO, INC.            Topic: NHLBI

    PROJECT SUMMARY - ResBiotic Inc. is developing its lead drug product, RB1000, a spray-dried powder com- prised of an inhaled biotherapeutic API for treatment of neutrophilic inflammation and disease progression in COPD patients. COPD is a chronic degenerative disease that is the fourth leading cause of death in the U.S., where it predominantly results from tobacco smoke exposure. Acute exacerbatio ...

    SBIR Phase I 2023 Department of Health and Human ServicesNational Institutes of Health
  7. Active Material Technology to Improve Solar Sail Performance for Space Weather Monitoring

    SBC: NEXOLVE HOLDING CO LLC            Topic: 96

    Development of a reflection control and direction device (RCDD) is proposed. This innovative device will progress the state of the art for propulsion of solar sails used to fly space weather monitoring sensors to sub-LaGrange point orbits for earlier warning times of impending destructive space weather events. A reflection control device (RCD) utilizes polymer dispersed liquid crystal (PDLC) mater ...

    SBIR Phase I 2023 Department of CommerceNational Oceanic and Atmospheric Administration
  8. Developing the Drought Risk Overview Product (DROP): Improving Flash Drought Forecasts and Early Warning Using Machine Learning and Extreme Value Theory Techniques

    SBC: CFD RESEARCH CORPORATION            Topic: 91

    Drought is responsible for $327.7B in economic loss since 1980 in the United States and typically precedes, cooccurs, or initiates other hazards like wildfires or prolonged periods of intense heat. The compounding or cascading of these hazards routinely threatens the wellbeing and stability of communities. The economic impact from drought can be especially harsh when the drought begins rapidly in ...

    SBIR Phase I 2023 Department of CommerceNational Oceanic and Atmospheric Administration
  9. Development of Patient Care Environment through Immersive Virtual Reality

    SBC: CFD RESEARCH CORPORATION            Topic: 20

    To develop an immersive VR environment where clinicians can interact with patients with rare diseases using virtual avatars.

    SBIR Phase II 2023 Department of Health and Human ServicesNational Institutes of Health
  10. Real-Time Quantitation of Transport Across Vascular-Tissue Interfaces in Organ-On-Chip Models Using In Situ Mass Spectrometry

    SBC: CFD RESEARCH CORPORATION            Topic: 400

    Abstract Current in vitro platforms are poor predictors of the in vivo safety, efficacy and pharmacokinetics of therapeutics, owing to a significant difference in the test conditions compared to physiological conditions. Therefore, drug toxicity testing is routinely performed using animal models. However, animal testing is expensive and time consuming. In addition, ethical concerns about the use o ...

    STTR Phase I 2022 Department of Health and Human ServicesNational Institutes of Health
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