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The Award database is continually updated throughout the year. As a result, data for the given year is not complete until April of the following year. Annual Reports data is a snapshot of agency reported information for that year and hence might look different from the live data in the Awards Information charts.

  1. Topic 375: 18F PET Tracer For Imaging PD-L1 (Moonshot)

    SBC: SIBTECH, INC.            Topic: NCI

    New therapies, designed to enhance anti-tumor immunity are based on the blockade of the checkpoint components, either PD-1 on immune cells or PD-L1 on tumor cells. This strategy, while being spectacularly successful in some patients for some cancers, fails for many other patients. The expression of PD-L1 is highly dynamic and its prevalence within tumors can vary significantly over time. The curre ...

    SBIR Phase I 2018 Department of Health and Human ServicesNational Institutes of Health
  2. A Rapid Low Cost Point of Care Diagnostic for detection of Zika virus RNA

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIAID

    ABSTRACT Zika virus ZIKV has rapidly emerged and spread through South and Central America the Caribbean and Puerto Rico since its last outbreak in Micronesia in Transmitted by the mosquito Aedes sp its forecasted spread will have a major impact on the Southeast U S Most ZIKV infections remain asymptomatic or present with non specific rash and fever therefore they have been difficult ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  3. Novel extracorporeal device Amytrapper to remove beta amyloid in Alzheimer s Disease

    SBC: RECOMBINANT TECHNOLOGIES LLC            Topic: N

    Abstract Alzheimer s disease AD is the most common cause of dementia among elderly patients afflicted by neurodegenerative diseases affecting about million people worldwide and regarded as the fourth most common cause of death Significant accumulation in the brain of Amyloid A is consistently observed in AD Due to its accumulation in AD removal of the toxic A from the system is expe ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  4. Rapid Detection of multiple sepsis pathogens

    SBC: TANGEN BIOSCIENCES, INC.            Topic: NIAID

    Abstract Sepsis is a major public health concern and the primary cause of death in the intensive care unit accounting for more than $ billion of total US hospital costs in Sepsis can lead to a life threatening drop in blood pressure termed septic shock which can quickly lead to the failure of vital organs such as lungs kidneys and liver and eventually to death Nearly all sepsi ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  5. Development of TP for the Induction and Maintenance of Remission in Ulcerative Colitis Patients

    SBC: Thetis Pharmaceuticals LLC            Topic: 300

    ABSTRACT Thetis plans to investigate TP an innovative and potential first in class therapeutic agent as an oral therapy for the induction and maintenance of remission of intestinal inflammation symptoms in ulcerative colitis UC patients While the precise etiology of UC is unknown it is thought to result from an inappropriate inflammatory response to commensal gut bacteria in genetically ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  6. Novel diagnostics for autoimmunity from checkpoint inhibitor immune therapy

    SBC: L2 DIAGNOSTICS, LLC            Topic: NIDDK

    Checkpoint inhibitor CPI therapy has transformed treatment of solid tumors Clinical responses in the range of with prolonged survival have been reported for tumors such as malignant melanoma and non small cell lung cancer that previously had poor response rates and dismal prognoses Current therapies block PD PD L and CTLA and there are other targets being developed such as LA ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  7. Waterproof Leadless Armband For Continuous Wireless Monitoring For Atrial Fibrillation

    SBC: MOBILE SENSE TECHNOLOGIES, INC.            Topic: NHLBI

    PROJECT SUMMARY ABSTRACT No longer than lines of text Atrial Fibrillation AF is the most common sustained dysrhythmia worldwide Although new AF treatment strategies have emerged over the last decade a major challenge facing clinicians and researchers is the paroxysmal often short lived and frequently asymptomatic nature of AF Paroxysmal and asymptomatic AF would be found i ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  8. Interactive Digital Intervention to Prevent Violence among Young Adults

    SBC: Happy People Games, LLC            Topic: NICHD

    Project Summary Abstract Sexual assault SA is prevalent among students at and year colleges The rate of SA among college students is three times greater than the rate in the general population making prevention on college campuses a public health priority There are no college SA prevention programs that document reductions in SA in a rigorous research design Digital applications that us ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  9. A novel approach to treat non alcoholic steatohepatitis NASH

    SBC: Mitotherapeutix LLC            Topic: 300

    Abstract The Specific Aim of this Phase I STTR proposal is to test the feasibility of treating non alcohol steatohepatitis NASH by increasing mitochondrial metabolism which is the main pathway for lipid catabolism in the liver NASH is a stage of non alcohol fatty liver disease NAFLD that has progressed to a pathological state NASH can lead to cirrhosis leading to liver failure or hepatocel ...

    STTR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health
  10. High Resolution Microbiome Profiling System

    SBC: SHORELINE BIOME, LLC            Topic: NIDA

    Shoreline Biome is developing kits methods and software as part of a comprehensive high resolution amplicon microbiome profiling system that revolutionizes ease of use while solving several problems with current S rRNA gene microbiome protocols The entire bp rRNA ITS gene space is targeted permitting veteran researchers to compare directly to previous assays encompassing any portion of t ...

    SBIR Phase I 2017 Department of Health and Human ServicesNational Institutes of Health

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